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首页> 外文期刊>Developmental biology >Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.
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Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.

机译：果蝇生卵过程中，果蝇的Rho激酶（DRok）是卵腔不同隔室中组织形态发生所必需的。

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The Rho-kinases are widely utilized downstream targets of the activated Rho GTPase that have been directly implicated in many aspects of Rho-dependent effects on F-actin assembly, acto-myosin contractility, and microtubule stability, and consequently play an essential role in regulating cell shape, migration, polarity, and division. We have determined that the single closely related Drosophila Rho-kinase ortholog, DRok, is required for several aspects of oogenesis, including maintaining the integrity of the oocyte cortex, actin-mediated tethering of nurse cell nuclei, "dumping" of nurse cell contents into the oocyte, establishment of oocyte polarity, and the trafficking of oocyte yolk granules. These defects are associated with abnormalities in DRok-dependent actin dynamics and appear to be mediated by multiple downstream effectors of activated DRok that have previously been implicated in oogenesis. DRok regulates at least one of these targets, the membrane cytoskeletal cross-linker DMoesin, via a direct phosphorylation that is required to promote localization of DMoesin to the oocyte cortex. The collective oogenesis defects associated with DRok deficiency reveal its essential role in multiple aspects of proper oocyte formation and suggest that DRok defines a novel class of oogenesis determinants that function as key regulators of several distinct actin-dependent processes required for proper tissue morphogenesis.
机译：Rho激酶是活化Rho GTP酶的广泛使用的下游靶标，直接与Rho依赖性F-肌动蛋白装配，肌动球蛋白收缩性和微管稳定性的许多方面有关，因此在调节中起着至关重要的作用。细胞的形状，迁移，极性和分裂。我们已经确定，单个紧密相关的果蝇Rho激酶直向同源物DRok是卵子发生的几个方面所必需的，包括维持卵母细胞皮层的完整性，肌动蛋白介导的护士细胞核系留，将护士细胞内容物“倾倒”卵母细胞，卵母细胞极性的建立以及卵母细胞卵黄颗粒的运输。这些缺陷与DRok依赖的肌动蛋白动力学异常有关，并且似乎是由活化DRok的多个下游效应子介导的，这些效应子先前已与卵子发生有关。 DRok通过直接磷酸化来调节这些靶标中的至少一个，即膜细胞骨架交联剂DMoesin，这是促进DMoesin定位于卵母细胞皮层所需的直接磷酸化作用。与DRok缺乏症相关的集体卵子发生缺陷揭示了其在正常卵母细胞形成的多个方面的重要作用，并表明DRok定义了一类新型卵子发生决定簇，其充当正常组织形态发生所需的几种不同肌动蛋白依赖性过程的关键调节因子。

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