Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains

Danielle R. Hamill; Aaron F. Severson; J. Clayton Carter; Bruce Bowerman

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Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains

机译：秀丽隐杆线虫的中心体成熟和有丝分裂纺锤体组装需要SPD-5，一种具有多个螺旋线圈结构域的蛋白质

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The maternally expressed C. elegans gene spd-5 encodes a centrosomal protein with multiple coiled-coil domains. During mitosis in mutants with reduced levels of SPD-5, microtubules assemble but radiate from condensed chromosomes without forming a spindle, and mitosis fails. SPD-5 is required for the centrosomal localization of γ-tubulin, XMAP-215, and Aurora A kinase family members, but SPD-5 accumulates at centrosomes in mutants lacking these proteins. Furthermore, SPD-5 interacts genetically with a dynein heavy chain. We propose that SPD-5, along with dynein, is required for centrosome maturation and mitotic spindle assembly.

机译：产妇表达的秀丽隐杆线虫基因spd-5编码具有多个卷曲螺旋结构域的中心体蛋白。在SPD-5含量降低的突变体的有丝分裂过程中，微管会聚集，但会从浓缩的染色体中放射出而不会形成纺锤体，有丝分裂会失败。 SPD-5是γ-微管蛋白，XMAP-215和Aurora A激酶家族成员在体中定位所必需的，但SPD-5会在缺乏这些蛋白的突变体中聚集在中心体上。此外，SPD-5与动力蛋白重链发生遗传相互作用。我们建议，SPD-5和动力蛋白是中心体成熟和有丝分裂纺锤体组装所必需的。

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《Developmental cell》 |2002年第5期|共12页
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Danielle R. Hamill; Aaron F. Severson; J. Clayton Carter; Bruce Bowerman;
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1. Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains [J] . Danielle R. Hamill, Aaron F. Severson, J. Clayton Carter, Developmental cell . 2002,第5期

机译：秀丽隐杆线虫的中心体成熟和有丝分裂纺锤体组装需要SPD-5，一种具有多个螺旋线圈结构域的蛋白质
2. Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. [J] . Sumiyoshi E, Sugimoto A, Yamamoto M Journal of Cell Science . 2002,第Pta7期

机译：秀丽隐杆线虫的有丝分裂和精子减数分裂的中心体成熟需要蛋白质磷酸酶4。
3. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos. [J] . Gomes JE, Encalada SE, Swan KA, Development . 2001,第21期

机译：母体基因spn-4编码早期秀丽隐杆线虫胚胎中有丝分裂纺锤体定向和细胞命运模式所需的预测RRM蛋白。
4. Measuring Proteins Across Developmental Stages of C. elegans Using Molecular Weight Fractionation and High-resolution Mass Spectrometry [C] . Gennifer E. Merrihew, Vagisha Sharma, James R. Hibbard, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：使用分子量分级和高分辨率质谱法测量杆状杆菌的发育阶段的蛋白质
5. Dynamic localization of the C. elegans GoLoco proteins GPR-1/2 mediates mitotic spindle orientation in response to extrinsic signals [D] . Werts, Adam David 2011

机译：秀丽隐杆线虫GoLoco蛋白GPR-1 / 2的动态定位介导有丝分裂纺锤体定向响应外部信号。
6. The RSA complex targets Protein Phosphatase 2A to centrosomes and regulates mitotic spindle assembly in C. elegans [O] . Anne-Lore Schlaitz, Martin Srayko, Alexander Dammermann, -1

机译：RSA复合物将蛋白磷酸酶2A靶向中心体并调节线虫的有丝分裂纺锤体组装
7. Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains [O] . Hamill Danielle R., Severson Aaron F., Carter J.Clayton, 2002

机译：秀丽隐杆线虫的中心体成熟和有丝分裂纺锤体装配需要SPD-5，一种具有多个螺旋线圈结构域的蛋白质
8. Kinesin-Related Protein Required for the Mitotic Spindle Assembly [R] . Walczak, C. E. 1999

机译：有丝分裂纺锤体装配所需的驱动蛋白相关蛋白

Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains

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