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A Unified Nomenclature for Yeast Autophagy-Related Genes

机译:酵母自噬相关基因的统一命名法

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摘要

Perhaps the most striking advantage of working with certain yeast systems is the ability to use genetic screens that allow a relatively rapid identification of genes involved in various biological processes. Because of its smaller size, the Saccharomyces cerevisiae genome was the first eukaryotic genome to be sequenced. Subsequent sequencing of genomes from higher eukaryotes has revealed what had already implicated from biochemical and molecular genetic studies performed over many years: homologs of yeast genes exist in other eukaryotes, and in many cases the corresponding gene products are orthologs that carry out similar functions (Reggiori and Klionsky, 2002). Accordingly, the analysis of genes and proteins in fungal cells has direct relevance for studies in other organisms.
机译:使用某些酵母系统最显着的优势可能是使用基因筛选的能力,该筛选可以相对快速地鉴定涉及各种生物学过程的基因。由于酿酒酵母基因组较小,因此它是第一个被测序的真核生物基因组。随后对高等真核生物进行基因组测序,揭示了多年来进行的生化和分子遗传学研究已经涉及的内容:酵母基因的同源物存在于其他真核生物中,并且在许多情况下,相应的基因产物是具有类似功能的直向同源物(Reggiori和Klionsky,2002年)。因此,真菌细胞中基因和蛋白质的分析与其他生物的研究直接相关。

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