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首页> 外文期刊>Developmental cell >The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.
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The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.

机译：染色体轴通过HORMA域蛋白的分级装配控制减数分裂事件。

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摘要

Proteins of the HORMA domain family play central, but poorly understood, roles in chromosome organization and dynamics during meiosis. In Caenorhabditis elegans, four such proteins (HIM-3, HTP-1, HTP-2, and HTP-3) have distinct but overlapping functions. Through combined biochemical, structural, and in?vivo analysis, we find that these proteins form hierarchical complexes through binding of their HORMA domains to cognate peptides within their partners' C-terminal tails, analogous to the "safety belt" binding mechanism of Mad2. These interactions are critical for recruitment of HIM-3, HTP-1, and HTP-2 to chromosome axes. HTP-3, in addition to recruiting the other HORMA domain proteins to the axis, plays an independent role in sister chromatid cohesion and double-strand break formation. Finally, we find that mammalian HORMAD1 binds a motif found both at its own C terminus and at that of HORMAD2, indicating that this mode of intermolecular association is a conserved feature of meiotic chromosome structure in eukaryotes.
机译：HORMA结构域家族的蛋白质在减数分裂过程中在染色体组织和动力学中起着核心作用，但鲜为人知。在秀丽隐杆线虫中，四种这样的蛋白质（HIM-3，HTP-1，HTP-2和HTP-3）具有不同但重叠的功能。通过组合的生化，结构和体内分析，我们发现这些蛋白通过其HORMA域与伴侣C末端尾巴内同源肽的结合形成了层次复合体，类似于Mad2的“安全带”结合机制。这些相互作用对于将HIM-3，HTP-1和HTP-2募集到染色体轴至关重要。 HTP-3除了将其他HORMA域蛋白募集到轴上之外，在姐妹染色单体内聚力和双链断裂的形成中也起着独立的作用。最后，我们发现哺乳动物HORMAD1结合在其自己的C末端和HORMAD2处均发现的基序，表明这种分子间缔合模式是真核生物减数分裂染色体结构的保守特征。

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