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Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif

机译：proneural bHLH和Brn蛋白通过协同结合保守的DNA基序来整合神经源性程序

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Proneural proteins play a central role in vertebrate neurogenesis, but little is known of the genes that they regulate and of the factors that interact with proneural proteins to activate a neurogenic program. Here, we demonstrate that the proneural protein Mash1 and the POU proteins Brn1 and Brn2 interact on the promoter of the Notch ligand Delta1 and synergistically activate Delta1 transcription, a key step in neurogenesis. Overexpression experiments in vivo indicate that Brn2, like Mash1, regulates additional aspects of neurogenesis, including the division of progenitors and the differentiation and migration of neurons. We identify by in silico screening a number of additional candidate target genes, which are recognized by Mash1 and Brn proteins through a DNA-binding motif similar to that found in the Delta1 gene and present a broad range of activities. We thus propose that Mash1 synergizes with Brn factors to regulate multiple steps of neurogenesis.

机译：proneural蛋白在脊椎动物神经发生中起着核心作用，但对其调节的基因以及与proneural蛋白相互作用以激活神经原性程序的因子知之甚少。在这里，我们证明proneural蛋白Mash1和POU蛋白Brn1和Brn2在Notch配体Delta1的启动子上相互作用，并协同激活Delta1转录，这是神经发生中的关键步骤。体内过表达实验表明，Brn2像Mash1一样，调控神经发生的其他方面，包括祖细胞的分裂以及神经元的分化和迁移。我们通过计算机筛选筛选出许多其他候选目标基因，这些目标基因通过与Delta1基因相似的DNA结合基序被Mash1和Brn蛋白识别，并具有广泛的活性。因此，我们建议Mash1与Brn因子协同调节神经发生的多个步骤。

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《Developmental cell》 |2006年第6期|共14页
作者
Castro DS; Skowronska-Krawczyk D; Armant O; Donaldson IJ; Parras C; Hunt C; Critchley JA; Nguyen L; Gossler A; Gottgens B;
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正文语种 eng
中图分类普通生物学;
关键词
MAMMALIAN ACHAETE-SCUTE; NEURONAL DIFFERENTIATION; TRANSCRIPTION FACTORS; NERVOUS-SYSTEM; CELL-MIGRATION; SPECIFICATION; GENES; EXPRESSION; TELENCEPHALON; ACTIVATION;

机译：哺乳动物沙门氏菌;神经分化;转录因子;神经系统;细胞迁移;规格;基因;表达;端粒;活化;

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1. Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif [J] . Castro DS, Skowronska-Krawczyk D, Armant O, Developmental cell . 2006,第6期

机译：proneural bHLH和Brn蛋白通过协同结合保守的DNA基序来整合神经源性程序
2. A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. [J] . Knoepfler PS, Bergstrom DA, Uetsuki T, Nucleic Acids Research . 1999,第18期

机译：肌原性bHLH转录因子的DNA结合域的N端保守基序介导了与pbx-Meis1 / Prep1的合作DNA结合。
3. A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with Pbx-Meis1/Prep1 [J] . Don A. Bergstrom, La Dac-Korytko, Mark P. Kamps, Nucleic acids research . 1999,第18期

机译：肌源性bHLH转录因子DNA结合结构域的N端保守基序介导与Pbx-Meis1 / Prep1的合作DNA结合
4. Towards an understanding of protein-protein interaction network hierarchies. Analysis of DnaN (β)-binding peptide motifs in members of protein families interacting with the eubacterial processivity clamp, the β subunit of DNA Polymerase III [C] . Brian P. Dalrymple, Gene Wijffels, Kritaya Kongsuwan, Asia-Pacific Bioinformatics Conference(APBC 2003); 200302; Adelaide(AU) . 2003

机译：对蛋白质-蛋白质相互作用网络层次结构的理解。蛋白质家族成员与DNA聚合酶III的优生过程性钳位相互作用的DnaN（β）结合肽基序分析
5. Escherichia coli DNA helicase II: Structure-function analysis of conserved amino acid motifs and investigation of protein-protein interactions [D] . Hall, Mark Christopher. 1998

机译：大肠杆菌DNA解旋酶II：保守氨基酸基序的结构功能分析和蛋白质-蛋白质相互作用的研究
6. A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. [O] . P S Knoepfler, D A Bergstrom, T Uetsuki, 1999

机译：肌原性bHLH转录因子的DNA结合域的N端保守基序介导与pbx-Meis1 / Prep1的合作DNA结合。
7. Proneural bHLH and Brn Proteins Coregulate a Neurogenic Program through Cooperative Binding to a Conserved DNA Motif [O] . Castro, Diogo S., Skowronska-Krawczyk, Dorota, Armant, Olivier, 2006

机译：神经性bHLH和Brn蛋白通过合作结合保守的DNa基序来调节神经源性程序

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