...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Developmental cell >A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning.
【24h】

A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning.

机译：胚胎组织模式中双功能转录因子信号传导的预测模型。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hedgehog signaling controls pattern formation in many vertebrate tissues. The downstream effectors of the pathway are the bifunctional Gli transcription factors, which, depending on hedgehog concentration, act as either transcriptional activators or repressors. Quantitatively understanding the interplay between Gli activator and repressor forms for patterning complex tissues is an open challenge. Here, we describe a reductionist mathematical model for how Gli activators and repressors are integrated in space and time to regulate transcriptional outputs of hedgehog signaling, using the pathway readouts Gli1 and Ptch1 as a model system. Spatially resolved measurements of absolute transcript numbers for these genes allow us to infer spatiotemporal variations of Gli activator and repressor levels. We validate our model by successfully predicting expression changes of Gli1 and Ptch1 in mutants at?different developmental stages and in different tissues. Our results provide a starting point for understanding gene regulation by bifunctional transcription factors during mammalian development.
机译：刺猬信号控制许多脊椎动物组织中的模式形成。该途径的下游效应子是双功能Gli转录因子，其取决于刺猬的浓度，充当转录激活因子或阻遏因子。定量了解Gli激活剂和阻遏物形式之间的相互作用以图案化复杂组织是一个开放的挑战。在这里，我们使用路径读数Gli1和Ptch1作为模型系统，描述了一个还原论者数学模型，该模型关于Gli激活因子和阻遏物如何在空间和时间上整合以调节刺猬信号的转录输出。这些基因的绝对转录本数量的空间分辨测量值使我们能够推断Gli激活子和阻遏物水平的时空变化。我们通过成功预测在不同发育阶段和不同组织中的突变体中Gli1和Ptch1的表达变化来验证我们的模型。我们的结果为了解哺乳动物发育过程中双功能转录因子的基因调控提供了一个起点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号