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首页> 外文期刊>Developmental cell >SETting the Stage: Eed-Enx1 Leaves an Epigenetic Signature on the Inactive X Chromosome
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SETting the Stage: Eed-Enx1 Leaves an Epigenetic Signature on the Inactive X Chromosome

机译:设置阶段:Eed-Enx1在非活性X染色体上留下表观遗传学签名

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摘要

Despite evidence implicating the Polycomb group protein, Eed (embryonic ectoderm development protein) in imprinted X inactivation, a similar role in random X inactivation in the embryo has remained an open question. Brockdorff and colleagues now report that Eed, along with its binding partner Enx1, transiently associates with the inactive X chromosome (Xi) and likely contributes to the epigenetic signature and longterm stability of the Xi heterochromatin.
机译:尽管有证据表明牵连的X失活涉及Polycomb组蛋白Eed(胚胎外胚层发育蛋白),但胚胎中随机X失活的类似作用仍然是一个悬而未决的问题。 Brockdorff及其同事现在报道,Eed及其结合伴侣Enx1瞬时与非活性X染色体(Xi)缔合,并可能有助于Xi异染色质的表观遗传学特征和长期稳定性。

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