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首页> 外文期刊>Developmental cell >Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling
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Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling

机译：通过时空调节的EGF受体信号传导在果蝇胚胎中的方形细胞包装。

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摘要

Cells display dynamic and diverse morphologies during development, but the strategies by which differentiated tissues achieve precise shapes and patterns are not well understood. Here we identify a developmental program that generates a highly ordered square cell grid in the Drosophila embryo through sequential and spatially regulated cell alignment, oriented cell division, and apicobasal cell elongation. The basic leucine zipper transcriptional regulator Cnc is necessary and sufficient to produce a square cell grid in the presence of a midline signal provided by the EGF receptor ligand Spitz. Spitz orients cell divisions through a Pins/LGN-dependent spindle-positioning mechanism and controls cell shape and alignment through a transcriptional pathway that requires the Pointed ETS domain protein. These results identify a strategy for producing ordered square cell packing configurations in epithelia and reveal a molecular mechanism by which organized tissue structure is generated through spatiotemporally regulated responses to EGF receptor activation.
机译：细胞在发育过程中表现出动态多样的形态，但是分化的组织获得精确形状和图案的策略还没有被很好地理解。在这里，我们确定了一个发育程序，该程序通过顺序和空间调节的细胞排列，定向的细胞分裂和apapobasal细胞伸长在果蝇胚胎中生成高度有序的方形细胞网格。在由EGF受体配体Spitz提供的中线信号存在下，基本的亮氨酸拉链转录调节子Cnc是必需的，并且足以产生方形细胞网格。 Spitz通过Pins / LGN依赖的纺锤定位机制来定向细胞分裂，并通过需要Pointed ETS域蛋白的转录途径控制细胞的形状和排列。这些结果确定了一种在上皮细胞中产生有序正方形细胞堆积结构的策略，并揭示了一种分子机制，通过该分子机制，通过对EGF受体激活的时空调节响应来产生组织的组织结构。

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