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首页> 外文期刊>Developmental cell >REI-1 Is a Guanine Nucleotide Exchange Factor Regulating RAB-11 Localization and Function in C. elegans Embryos
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REI-1 Is a Guanine Nucleotide Exchange Factor Regulating RAB-11 Localization and Function in C. elegans Embryos

机译：REI-1是鸟嘌呤核苷酸交换因子，可调节线虫胚胎中RAB-11的定位和功能。

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摘要

The small GTPase Rab11 dynamically changes its location to regulate various cellular processes such as endocytic recycling, secretion, and cytokinesis. However, our knowledge of its upstream regulators is still limited. Here, we identify the RAB-11-interacting protein-1 (REI-1) as a unique family of guanine nucleotide exchange factors (GEFs) for RAB-11 in Caenorhabditis elegans. Although REI-1 and its human homolog SH3-binding protein 5 do not contain any known Rab-GEF domains, they exhibited strong GEF activity toward Rab11 in vitro. In C. elegans, REI-1 is expressed in the germline and co-localizes with RAB-11 on the late-Golgi membranes. The loss of REI-1 specifically impaired the targeting of RAB-11 to the late-Golgi compartment and the recycling endosomes in embryos and further reduced the RAB-11 distribution to the cleavage furrow, which resulted in cytokinesis delay. These results suggest that REI-1 is a GEF specifically regulating the RAB-11 localization and functions in early embryos.
机译：小型GTPase Rab11可动态改变其位置，以调节各种细胞过程，例如内吞再循环，分泌和胞质分裂。但是，我们对其上游调节器的了解仍然有限。在这里，我们确定RAB-11-相互作用蛋白1（REI-1）为秀丽隐杆线虫中RAB-11的鸟嘌呤核苷酸交换因子（GEFs）的独特家族。尽管REI-1及其人类同源物SH3结合蛋白5不包含任何已知的Rab-GEF域，但它们在体外对Rab11表现出强大的GEF活性。在秀丽隐杆线虫中，REI-1在种系中表达，并与高尔基晚期膜上的RAB-11共定位。 REI-1的丢失会特别破坏RAB-11靶向晚期高尔基体和胚胎中的回收内体，并进一步降低RAB-11分布至分裂沟，从而导致胞质分裂延迟。这些结果表明，REI-1是一种GEF，专门调节早期胚胎中RAB-11的定位和功能。

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