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首页> 外文期刊>Digestive Diseases and Sciences >Pringle maneuver deteriorates gut barrier dysfunction induced by extended-liver radiofrequency ablation.
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Pringle maneuver deteriorates gut barrier dysfunction induced by extended-liver radiofrequency ablation.

机译：品酒动作使由延长肝脏射频消融引起的肠屏障功能障碍恶化。

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摘要

BACKGROUND: Large volume radiofrequency ablation (RFA) of the liver disrupts intestinal mucosa barrier with subsequent bacterial translocation. AIMS: To investigate the effect of the Pringle maneuver applied concurrently with extended liver RFA on gut barrier integrity and bacterial translocation. MATERIALS AND METHODS: Rats were subjected to 30% liver RFA following laparotomy (group RFA), RFA plus 30 min Pringle (group RFA + P), Pringle (group P) or sham operation (group S). Intestinal tissue specimens were excised for histopathological examination and assessment of mucosal morphometry, apoptotic activity, mitotic activity and oxidative state. Tissue specimens were collected from the mesenteric lymph nodes, non-ablated liver parenchyma, kidneys and lungs for bacterial culture. Blood samples were collected from the portal and systemic circulation for endotoxin level measurement. RESULTS: In group RFA + P, intestinal histopathologic lesions, mucosal atrophy and crypt cell apoptosis were more prominent compared to group RFA. Mitotic activity was suppressed. Oxidative stress was equally induced in all experimental groups. The incidence of positive bacterial cultures, bacterial counts and endotoxin levels were higher in group RFA + P compared to the other groups. CONCLUSION: The application of the Pringle maneuver concurrently with extended liver RFA aggravates gut barrier dysfunction with more aggressive translocation of endotoxins and intestinal bacteria.
机译：背景：肝脏的大量射频消融（RFA）会破坏肠粘膜屏障，并随后引起细菌移位。目的：研究普林格尔（Pringle）手术与延长的肝RFA同时应用对肠屏障完整性和细菌移位的影响。材料与方法：开腹手术（RFA组），RFA加30分钟的Pringle（RFA + P组），Pringle（P组）或假手术（S组）后，大鼠接受30％的肝脏RFA。切除肠组织标本用于组织病理学检查和评估粘膜形态，凋亡活性，有丝分裂活性和氧化状态。从肠系膜淋巴结，未消融的肝实质，肾脏和肺中收集组织标本进行细菌培养。从门脉和全身循环中收集血样用于内毒素水平的测量。结果：RFA + P组与RFA组相比，肠道组织病理学病变，粘膜萎缩和隐窝细胞凋亡更为突出。有丝分裂活性受到抑制。在所有实验组中均相同地诱导了氧化应激。与其他组相比，RFA + P组的阳性细菌培养物，细菌数量和内毒素水平的发生率更高。结论：Pringle动作与延长的肝RFA同时应用会加重肠屏障功能障碍，使内毒素和肠道细菌更易移位。

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