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首页> 外文期刊>Digestive Diseases and Sciences >Influence of age and HBeAg status on the correlation between HBV DNA and hepatic inflammation and fibrosis in chronic hepatitis B patients
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Influence of age and HBeAg status on the correlation between HBV DNA and hepatic inflammation and fibrosis in chronic hepatitis B patients

机译：年龄和HBeAg状态对慢性乙型肝炎患者HBV DNA与肝炎症和纤维化相关性的影响

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Aims: The purpose of this study was to examine the correlation between serum HBV DNA level and the severity of hepatic inflammation and fibrosis in patients with chronic hepatitis B. Methods: Liver function, serological markers of HBV and serum HBV DNA quantification were assayed in 215 CHB patients who also underwent liver biopsy. Liver pathology was regarded as the evaluation criteria to evaluate the correlation between serum HBV DNA level and the severity of liver inflammation and fibrosis. Results: Of the 215 patients, 136 were HBeAg-positive and 79 were HBeAg-negative; 134 patients had mild hepatic inflammation and fibrosis and 81 had significant hepatic inflammation and fibrosis in pathological diagnosis. We found that positive correlation between the severity of hepatic inflammation and fibrosis and serum HBV DNA level was only present in HBeAg-negative patients but not HBeAg-positive patients (P < 0.001). Patients' age was a key factor influencing the correlation between serum HBV DNA level and the severity of hepatic inflammation and fibrosis. the cutoff values to predict the severity of hepatic inflammation and fibrosis were 33.5 and 36 years, respectively. Using 35 years as the cutoff value, positive correlation between serum HBV DNA level and hepatic inflammation and fibrosis was observed in both HBeAg-positive and HBeAg-negative patients aged ≥35 years (P < 0.05), however no correlation was observed in HBeAg-positive patients aged <35 years. Conclusions: There was positive correlation between serum HBV DNA level and hepatic inflammation and fibrosis in both HBeAg-positive and HBeAg-negative patients' aged ≥35 years, but in patients aged <35 years, positive correlation was only observed in HBeAg-negative patients.
机译：目的：本研究旨在探讨慢性乙型肝炎患者血清HBV DNA水平与肝炎和纤维化严重程度之间的相关性。方法：在215中测定肝功能，HBV血清学标志物和血清HBV DNA定量还接受肝活检的CHB患者。肝病理学被认为是评估血清HBV DNA水平与肝脏炎症和纤维化严重程度之间相关性的评估标准。结果：215例患者中，HBeAg阳性136例，HBeAg阴性79例。在病理诊断中，有134例轻度肝炎和纤维化患者，其中81例有明显的肝炎和纤维化。我们发现，仅在HBeAg阴性患者中存在肝炎症和纤维化的严重程度与血清HBV DNA水平之间的正相关（P <0.001）。患者年龄是影响血清HBV DNA水平与肝炎和纤维化严重程度之间相关性的关键因素。预测肝炎症和纤维化严重程度的临界值分别为33.5岁和36岁。以35岁作为截止值，≥35岁的HBeAg阳性和HBeAg阴性患者的血清HBV DNA水平与肝炎症和纤维化之间呈正相关（P <0.05），但在HBeAg-年龄<35岁的阳性患者。结论：≥35岁的HBeAg阳性和HBeAg阴性的患者血清HBV DNA水平与肝炎症和纤维化呈正相关，而＜35岁的患者中，仅HBeAg阴性的患者呈正相关。 。

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