Withdrawal of Long-Term Maintenance Treatment with Azathioprine Tends to Increase Relapse Risk in Patients with Crohn's Disease

Wenzl Heimo H.; Primas Christian; Novacek Gottfried; Teml Alexander; Oefferlbauer-Ernst Anna; Hoegenauer Christoph; Vogelsang Harald; Petritsch Wolfgang; Reinisch Walter

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Withdrawal of Long-Term Maintenance Treatment with Azathioprine Tends to Increase Relapse Risk in Patients with Crohn's Disease

机译：停用硫唑嘌呤的长期维持治疗倾向于增加克罗恩病患者的复发风险

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Background and Aim Many patients with quiescent Crohn's disease are maintained on long-term treatment with azathioprine (AZA), but controlled data are limited. We aimed to evaluate the efficacy of AZA therapy for more than 4 years to maintain clinical remission.

机译：背景与目的许多患有克罗恩病的静态患者接受硫唑嘌呤（AZA）的长期治疗，但控制数据有限。我们旨在评估AZA治疗4年以上以维持临床缓解的疗效。

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《Digestive Diseases and Sciences》 |2015年第5期|共10页
作者
Wenzl Heimo H.; Primas Christian; Novacek Gottfried; Teml Alexander; Oefferlbauer-Ernst Anna; Hoegenauer Christoph; Vogelsang Harald; Petritsch Wolfgang; Reinisch Walter;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Crohn's disease; Immunomodulators; Azathioprine; Clinical trails;

机译：克罗恩病;免疫调节剂;硫唑嘌呤;临床试验;

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1. Withdrawal of Long-Term Maintenance Treatment with Azathioprine Tends to Increase Relapse Risk in Patients with Crohn's Disease [J] . Wenzl Heimo H., Primas Christian, Novacek Gottfried, Digestive Diseases and Sciences . 2015,第5期

机译：停用硫唑嘌呤的长期维持治疗倾向于增加克罗恩病患者的复发风险
2. Withdrawal of Azathioprine in Inflammatory Bowel Disease Patients Who Sustain Remission: New Risk Factors for Relapse [J] . Iborra Marisa, Herreras Julia, Maia Bosca-Watts Marta, Digestive Diseases and Sciences . 2019,第6期

机译：在维持缓解的炎症性肠病患者中撤离Azathioprine：复发的新风险因素
3. Relapse rate following azathioprine withdrawal in maintaining remission for Crohn's disease: a meta-analysis. [J] . French H, Mark Dalzell A, Srinivasan R, Digestive Diseases and Sciences . 2011,第7期

机译：在维持克罗恩病缓解后，硫唑嘌呤停药后的复发率：一项荟萃分析。
4. Increased risk of morbidity associated with immunomodulatory treatment in patients with inflammatory bowel diseases [C] . J.-F. COLOMBEL, M. TORUNE Falk Symposium . 2007

机译：炎症性肠病患者的发病率增加了与免疫调节治疗有关的发病危险
5. The Comparison of Prescriptions Dispensed For Methadone Maintenance Patients to Non-Methadone Maintenance Patients for the Treatment of Chronic Diseases using PharmaNet Data [D] . Maruyama, Anna. 2012

机译：使用PharmaNet数据比较美沙酮维持治疗患者和非美沙酮维持治疗患者治疗慢性疾病的处方比较
6. Thalidomide Combined With Azathioprine as Induction and Maintenance Therapy for Azathioprine-Refractory Crohns Disease Patients [O] . Tong Li, Yun Qiu, Xiaozhi Li, 2020

机译：沙利度胺联合Azathioprine作为抑制和维持治疗的AzathioLne-Refracty Crohn病患者
7. Randomized controlled azathioprine withdrawal after more than two years treatment in Crohn's disease: increased relapse rate the following year [O] . M. Vilien, J. F. Dahlerup, L. K. Munck, 2004

机译：随机控制的杜鹃花升级后克罗恩病两年以上的治疗方法：次年增加复发率

Withdrawal of Long-Term Maintenance Treatment with Azathioprine Tends to Increase Relapse Risk in Patients with Crohn's Disease

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