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首页> 外文期刊>Digestive Diseases and Sciences >Incidence of esophageal carcinoma among Malays in North-Eastern Peninsular Malaysia: an area with an exceptionally low prevalence of Helicobacter pylori infection.
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Incidence of esophageal carcinoma among Malays in North-Eastern Peninsular Malaysia: an area with an exceptionally low prevalence of Helicobacter pylori infection.

机译：马来西亚东北半岛马来人中食道癌的发病率：幽门螺杆菌感染率极低的地区。

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BACKGROUND: Obesity, gastroesophageal reflux, and Barrett's esophagus have all been linked to esophageal adenocarcinoma. In addition, the decline in Helicobacter pylori (H. pylori) infection in affluent societies has also been suggested to be a major factor in the recent rise in the incidence of esophageal adenocarcinoma. If H. pylori infection has a protective role, populations with a naturally low prevalence of H. pylori infection such as the ethnic Malays of Northeastern Peninsular Malaysia should have high rates of esophageal adenocarcinoma. AIM: To test this hypothesis, we investigated the incidence of esophageal carcinoma among the ethnic Malays of the state of Kelantan in Northeastern Peninsular Malaysia. METHODS: The pathology services in the state of Kelantan are provided by two main hospitals. The histopathological records of both hospitals were systematically examined to retrieve all cases of esophageal carcinoma diagnosed between 2004 and 2008. Incidence rates were determined based on the most recent population census. RESULTS: The age-standardized incidence rates (per 100,000 population) of esophageal adenocarcinoma among Malay men and women were 0.75 and 0.69, respectively. The corresponding rates for squamous cell carcinoma of the esophagus were 0.66 and 1.34, respectively. CONCLUSIONS: The low rates of adenocarcinoma and squamous cell carcinoma of the esophagus in the study area, despite the fact that H. pylori infection is virtually absent, does not support the hypothesis that the absence of H. pylori infection is a pivotal factor in the pathogenesis of these cancers.
机译：背景：肥胖，胃食管反流和巴雷特食管均与食管腺癌有关。此外，富裕社会中幽门螺杆菌（H. pylori）感染的减少也被认为是最近食管腺癌发病率上升的主要因素。如果幽门螺杆菌感染具有保护作用，那么自然界中幽门螺杆菌感染率较低的人群，例如马来西亚东北半岛的马来人，就应该有较高的食道腺癌发生率。目的：为检验这一假设，我们调查了马来西亚东北半岛吉兰丹州马来人中食道癌的发生率。方法：吉兰丹州的病理服务由两家主要医院提供。系统地检查了两家医院的组织病理学记录，以检索2004年至2008年之间诊断出的所有食道癌病例。根据最近的人口普查确定发病率。结果：马来人男女食管腺癌的年龄标准化发病率（每100,000人）分别为0.75和0.69。食管鳞状细胞癌的相应发生率分别为0.66和1.34。结论：尽管事实上没有幽门螺杆菌感染，但研究区域食管腺癌和鳞状细胞癌的发生率较低，这并不支持以下假设：没有幽门螺杆菌感染是导致食管癌的关键因素。这些癌症的发病机理。

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