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首页> 外文期刊>Digestive Diseases and Sciences >Visceral and somatic hypersensitivity in TNBS-induced colitis in rats.
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Visceral and somatic hypersensitivity in TNBS-induced colitis in rats.

机译：TNBS诱发的大鼠结肠炎的内脏和躯体超敏反应。

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摘要

Inflammation of visceral structures in rats has been shown to produce visceral/somatic hyperalgesia. Our objectives were to determine if trinitrobenzene sulfonic acid (TNBS) induced colitis in rats leads to visceral/somatic hypersensitivity. Male Sprague-Dawley rats (200-250 g) were treated with 20 mg of TNBS in 50% ethanol (n = 40) or an equivalent volume of ethanol (n = 40) or saline (n = 25) via the colon. Colonic distension, Von Frey, Hargreaves, and tail reflex tests were used to evaluate for visceral, mechanical, and thermal sensitivity. The rats demonstrated visceral hypersensitivity at 2-28 days following TNBS administration (P < 0.0001). The ethanol-treated rats also demonstrated visceral hypersensitivity that resolved after day 14. TNBS-treated rats demonstrated somatic hypersensitivity at days 14-28 (P < 0.0001) in response to somatic stimuli of the hind paw. TNBS colitis is associated with visceral and somatic hypersensitivity in areas of somatotopic overlap. This model of colitis should allow further investigation into the mechanisms of visceral and somatic hypersensitivity.
机译：已经显示，大鼠内脏结构的炎症会产生内脏/躯体痛觉过敏。我们的目标是确定三硝基苯磺酸（TNBS）诱导的大鼠结肠炎是否导致内脏/躯体超敏反应。雄性Sprague-Dawley大鼠（200-250 g）通过结肠用含50％乙醇（n = 40）或等体积乙醇（n = 40）或生理盐水（n = 25）中的20 mg TNBS处理。结肠扩张，冯·弗雷（Von Frey），哈格里夫斯（Hargreaves）和尾巴反射测试用于评估内脏，机械和热敏感性。在TNBS给药后2-28天，大鼠表现出内脏超敏反应（P <0.0001）。乙醇处理的大鼠还表现出内脏超敏反应，在第14天后消失。TNBS处理的大鼠在第14-28天表现出对后爪的体细胞刺激作出反应的体细胞超敏反应（P <0.0001）。 TNBS结肠炎与体位重叠区域的内脏和躯体过敏有关。这种结肠炎模型应允许进一步研究内脏和躯体超敏反应的机制。

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