The influence of formulation factors on the kinetic release of metoprolol tartrate from prolong release coated minitablets.

Tomuta I; Leucuta SE

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The influence of formulation factors on the kinetic release of metoprolol tartrate from prolong release coated minitablets.

机译：制剂因素对酒石酸美托洛尔从缓释包衣小片剂中动态释放的影响。

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The aim of this work was to study the possibility to obtain an oral extended-release dosage forms with zero order kinetic release by coating minitablets (containing metoprolol tartrate) with insoluble methacrylate film coating (Eudragit NE 40D) in a fluidized bed system. To achieve this aim a full factorial experimental design with two factors and three levels was used in order to study de influence of the amount of polymer film formatting (Eudragit NE 40D) and the amount of pore generating excipient in polymeric insoluble film (low viscosity hydroxypropyl methylcellulose-Methocel E 15LV) on the in vitro drug release profile.

机译：这项工作的目的是研究通过在流化床系统中用不溶性甲基丙烯酸酯薄膜衣料（Eudragit NE 40D）包衣微型片剂（含有酒石酸美托洛尔）来获得零级动力学释放的口服缓释剂型的可能性。为了达到这个目的，使用了具有两个因素和三个层次的全因子实验设计，以研究聚合物膜形成量（Eudragit NE 40D）和聚合物不溶性膜（低粘度羟丙基）中产生孔的赋形剂的量的影响。甲基纤维素-Methocel E 15LV）的体外药物释放曲线。

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《Drug development and industrial pharmacy》 |2007年第10期|共8页
作者
Tomuta I; Leucuta SE;
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正文语种 eng
中图分类药学;
关键词
Chemistry; Pharmaceutical; Kinetics; Metoprolol; Tablets; 化学; 药物; 动力学; 美托洛尔; 片剂;

机译：Chemistry;Pharmaceutical;Kinetics;Metoprolol;Tablets;化学;药物;动力学;美托洛尔;片剂;

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1. The influence of formulation factors on the kinetic release of metoprolol tartrate from prolong release coated minitablets. [J] . Tomuta I, Leucuta SE Drug development and industrial pharmacy . 2007,第10期

机译：制剂因素对酒石酸美托洛尔从缓释包衣小片剂中动态释放的影响。
2. Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended‐Release Products [J] . Basu Sumit, Yang Haitao, Fang Lanyan, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2019,第9期

机译：基于生理学的药代动力学模型，评估影响美容额外释放产品的生物等效性的配方因素
3. Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended‐Release Products [J] . The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2019,第9期

机译：基于生理学的药代动力学模型，评估影响美容额外释放产品的生物等效性的配方因素
4. Development of an in vitro-in vivo correlation for a metoprolol-tartrate modified release formulation prepared by melt extrusion technology [C] . J.Breitenbach, S.Koehne, M.Maegerlein, . 2000

机译：通过熔融挤出技术制备的酒石酸美托洛尔缓释制剂的体内外相关性开发
5. Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors. [D] . Fahmy, Sahar Abd El-Sattar. 2004

机译：硝苯地平新型喷雾包衣的软弹性明胶胶囊缓释制剂的开发，维拉帕米盐酸盐控释制剂的生物利用度和生物等效性，在猛禽中单次口服剂量后特比萘芬的药代动力学。
6. Formulation and evaluation of controlled release ethylcellulose and polyethylene glycol microspheres containing metoprolol tartrate [O] . Venkata Ramana Malipeddi, Rajendra Awasthi, Kamal Dua 2016

机译：酒石酸美托洛尔的控释乙基纤维素和聚乙二醇微球的配制与评价
7. Influence of formulation factors and compression force on release profile of sustained release metoprolol tablets using compritol®888ato as lipid excipient [O] . MangalS Nagarsenker, ShilpaN Patere, ChhandaJ Kapadia 2015

机译：配方因子和压缩力对脂质赋形剂的持续释放茂物片释放谱的影响

The influence of formulation factors on the kinetic release of metoprolol tartrate from prolong release coated minitablets.

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