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首页> 外文期刊>Dose-response >Protective effect of γ-irradiation against hypochlorous acid-induced haemolysis in human erythrocytes
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Protective effect of γ-irradiation against hypochlorous acid-induced haemolysis in human erythrocytes

机译：γ射线对次氯酸诱导的人红细胞溶血的保护作用

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摘要

Radiations may trigger protective response within a threshold of doses applied. Exposures above an upper threshold are generally detrimental, while exposures below a lower threshold may or may not increase risks for health. We recently reported that a cellular protective response occurs in interventional cardiologists to counteract the oxidative damage caused by radiation. Here, we demonstrated in an in vitro model represented by whole blood of healthy donors γ-irradiated with 220-440 mGy, that haemolysis of erythrocytes induced by hypochlorous acid was reduced by 40%. The protection triggered by γ- radiations made erythrocytes more resistant to oxidative insult caused by hypochlorous acid which was induced 3 h after irradiation and involved biochemical changes in the synthesis and turnover of glutathione. Overall, the biochemical remodelling induced by exposure to γ-radiations might contribute to generate new guidelines in professionally exposed workers.
机译：辐射可在施加剂量的阈值内触发保护性反应。高于最高阈值的暴露通常是有害的，而低于较低阈值的暴露则可能会或可能不会增加健康风险。我们最近报道说，介入心脏病学家会发生细胞保护反应，以抵消由辐射引起的氧化损伤。在此，我们在以健康供体γ辐射220-440 mGy的全血为代表的体外模型中证明，次氯酸诱导的红细胞溶血减少了40％。 γ射线引发的保护作用使红细胞对次氯酸引起的氧化损伤更具抵抗力，次氯酸在辐射后3小时被诱导，涉及谷胱甘肽的合成和周转过程中的生化变化。总体而言，由暴露于γ射线引起的生化重塑可能有助于在职业接触工人中产生新的指导方针。

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