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Effects of low-dose-gamma rays on the immune system of different animal models of disease

机译：低剂量γ射线对不同疾病动物模型免疫系统的影响

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We reviewed the beneficial or harmful effects of low-dose ionizing radiation on several diseases based on a search of the literature. The attenuation of autoimmune manifestations in animal disease models irradiated with low-dose γ-rays was previously reported by several research groups, whereas the exacerbation of allergic manifestations was described by others. Based on a detailed examination of the literature, we divided animal disease models into two groups: one group consisting of collagen-induced arthritis (CIA), experimental encephalomyelitis (EAE), and systemic lupus erythematosus, the pathologies of which were attenuated by low-dose irradiation, and another group consisting of atopic dermatitis, asthma, and Hashimoto's thyroiditis, the pathologies of which were exacerbated by low-dose irradiation. The same biological indicators, such as cytokine levels and Tcell subpopulations, were examined in these studies. Low-dose irradiation reduced interferon (IFN)-gamma (γ) and interleukin (IL)-6 levels and increased IL-5 levels and the percentage of CD4+ CD25+ Foxp3+ Treg cells in almost all immunological disease cases examined. Variations in these biological indicators were attributed to the attenuation or exacerbation of the disease's manifestation. We concluded that autoimmune diseases caused by autoantibodies were attenuated by low-dose irradiation, whereas diseases caused by antibodies against external antigens, such as atopic dermatitis, were exacerbated.
机译：基于文献检索，我们综述了低剂量电离辐射对几种疾病的有益或有害影响。几个研究小组先前曾报道用低剂量γ射线辐照的动物疾病模型中自身免疫表现的减弱，而其他人则描述了过敏表现的加剧。在详细研究文献的基础上，我们将动物疾病模型分为两组：一组由胶原诱导的关节炎（CIA），实验性脑脊髓炎（EAE）和系统性红斑狼疮组成，其病因被低密度脂蛋白减轻剂量照射，另一组由特应性皮炎，哮喘和桥本氏甲状腺炎组成，低剂量照射会加剧病理。在这些研究中检查了相同的生物学指标，例如细胞因子水平和T细胞亚群。在几乎所有免疫疾病病例中，低剂量照射均可降低干扰素（IFN）-γ（γ）和白介素（IL）-6的水平，并提高IL-5的水平以及CD4 + CD25 + Foxp3 + Treg细胞的百分比。这些生物学指标的差异归因于该疾病表现的减弱或加剧。我们得出的结论是，低剂量照射可减轻由自身抗体引起的自身免疫性疾病，而由外部抗原抗体引起的疾病（如特应性皮炎）则会加剧。

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