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首页> 外文期刊>Drug discovery today >Keynote review: the adipocyte as a drug discovery target.
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Keynote review: the adipocyte as a drug discovery target.

机译:主题演讲:脂肪细胞作为药物发现靶标。

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摘要

The adipocyte has pleiotropic functions beyond the storage of energy in times of nutrient abundance. Considerable efforts in adipocyte biology within the past ten years have emphasized the important role of adipose tissue in processes as diverse as energy metabolism, inflammation and cancer. Adipocytes are able to communicate with the brain and peripheral tissues implementing metabolic signals such as satiety, food intake and energy expenditure. Despite its huge pharmacological potential, only a small number of clinical applications interfere directly with adipocyte physiology. Here, we want to highlight various areas of adipocyte physiology that have not yet been explored pharmacologically and emphasize some of the limitations associated with these pharmacotherapies.
机译:脂肪细胞在营养丰富时具有多能功能,不只是能量存储。在过去的十年中,脂肪细胞生物学方面的大量努力强调了脂肪组织在能量代谢,炎症和癌症等各种过程中的重要作用。脂肪细胞能够与大脑和周围组织进行通讯,实现新陈代谢信号,例如饱腹感,食物摄入和能量消耗。尽管具有巨大的药理潜力,但只有少数临床应用直接干扰脂肪细胞生理。在这里,我们要强调尚未进行药理学探讨的脂肪细胞生理学的各个领域,并强调与这些药物疗法相关的某些局限性。

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