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首页> 外文期刊>Drug discovery today >Status of terpenes as skin penetration enhancers.
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Status of terpenes as skin penetration enhancers.

机译：萜烯作为皮肤渗透促进剂的地位。

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摘要

Since its introduction, transdermal drug delivery has promised much but, in some respects has still to deliver on that initial promise, due to inherent limitations imposed by the percutaneous route. The greatest obstacle for transdermal delivery is the barrier property of the stratum corneum. Many approaches have been employed to breach the skin barrier, of which, the most widely used one is that of chemical penetration enhancers. Of the penetration enhancers, terpenes are arguably the most highly advanced and proven category and are classified as generally regarded as safe (GRAS) by the Food and Drug Administration. This paper presents an overview of the investigations on the feasibility and application of terpenes as sorption promoters for improved delivery of drugs through skin.
机译：自从引入以来，经皮药物递送已经有很多希望，但是由于经皮途径施加的固有局限性，在某些方面仍必须履行最初的希望。透皮递送的最大障碍是角质层的阻隔性能。已经采用许多方法来突破皮肤屏障，其中最广泛使用的一种是化学渗透促进剂。在渗透促进剂中，萜烯可以说是最先进和最成熟的类别，被美国食品药品管理局（FDA）归类为安全（GRAS）。本文概述了萜烯作为吸附促进剂以改善药物通过皮肤递送的可行性和应用的研究概况。

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