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首页> 外文期刊>Drug discovery today >Vaccines against intracellular bacterial pathogens.
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Vaccines against intracellular bacterial pathogens.

机译：针对细胞内细菌病原体的疫苗。

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摘要

There is a long history of remarkable success in developing vaccines against bacteria that are extracellular pathogens. In general, the development of vaccines against intracellular bacterial pathogens has proven to be more challenging. Typically, such vaccines need to induce a range of immune responses, including antibody, CD4(+) and CD8(+) T cell responses. These responses can be induced by live attenuated vaccines, but eliciting these responses with non-living vaccines has proven to be difficult. The difficulties appear to be related partly to the problems associated with the identification of protective antigens and partly with the difficulties associated with inducing CD8(+) T cell responses.
机译：在开发针对作为细胞外病原体的细菌的疫苗方面，已有悠久的成功历史。通常，已证明开发针对细胞内细菌病原体的疫苗更具挑战性。通常，此类疫苗需要诱导一系列免疫应答，包括抗体，CD4（+）和CD8（+）T细胞应答。减毒活疫苗可以诱导这些应答，但是用非活疫苗激发这些应答已被证明是困难的。困难似乎部分与鉴定保护性抗原有关的问题有关，部分与诱导CD8（+）T细胞反应有关的困难有关。

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