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首页> 外文期刊>Drug discovery today >Function and regulation of large conductance Ca 2+-activated K + channel in vascular smooth muscle cells
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Function and regulation of large conductance Ca 2+-activated K + channel in vascular smooth muscle cells

机译：大电导Ca 2+激活的K +通道在血管平滑肌细胞中的功能和调控

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摘要

Large conductance Ca 2+-activated K + (BK Ca) channels are abundantly expressed in vascular smooth muscle cells. Activation of BK Ca channels leads to hyperpolarization of cell membrane, which in turn counteracts vasoconstriction. Therefore, BK Ca channels have an important role in regulation of vascular tone and blood pressure. The activity of BK Ca channels is subject to modulation by various factors. Furthermore, the function of BK Ca channels are altered in both physiological and pathophysiological conditions, such as pregnancy, hypertension and diabetes, which has dramatic impacts on vascular tone and hemodynamics. Consequently, compounds and genetic manipulation that alter activity and expression of the channel might be of therapeutic interest.
机译：大电导Ca 2+激活的K +（BK Ca）通道在血管平滑肌细胞中大量表达。 BK Ca通道的激活会导致细胞膜超极化，进而抵消血管收缩。因此，BK Ca通道在调节血管紧张度和血压中起重要作用。 BK Ca通道的活性受各种因素的调节。此外，BK Ca通道的功能在生理和病理生理条件（例如妊娠，高血压和糖尿病）中均发生改变，这对血管张力和血液动力学具有显着影响。因此，改变通道活性和表达的化合物和遗传操作可能具有治疗意义。

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