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首页> 外文期刊>Drug discovery today >What is the most important approach in current drug discovery: Doing the right things or doing things right?
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What is the most important approach in current drug discovery: Doing the right things or doing things right?

机译：当前药物发现中最重要的方法是：做正确的事或做正确的事？

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摘要

Doing the right things or doing things right: what is the most important focus for current drug discovery to secure delivery of new drugs of sustainable value to patients, healthcare professionals and healthcare providers? Some of the challenges faced today in drug discovery are addressed here: the relationship between R&D speed, cost and quality; how selection of performance metrics can affect the quality of the R&D output; the importance of leadership and management; how process orientation can affect, for example, creativity and innovation; the importance of selecting the right pharmacologic target and the right chemical lead; and why the use of drug-target kinetic and thermodynamic data to drive lead selection and lead optimization could increase success rates.
机译：做正确的事或做正确的事：当前药物发现最重要的重点是确保向患者，医疗保健专业人员和医疗保健提供者提供具有可持续价值的新药物？当今，在药物研发中面临的一些挑战已在此处解决：研发速度，成本和质量之间的关系;选择绩效指标如何影响研发产出的质量;领导和管理的重要性;过程导向如何影响例如创造力和创新;选择正确的药理学目标和正确的化学铅的重要性;以及为什么使用药物靶标动力学和热力学数据来驱动线索选择和线索优化可以提高成功率。

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