...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug discovery today >Drugs from the deep: marine natural products as drug candidates.
【24h】

Drugs from the deep: marine natural products as drug candidates.

机译：来自深海的毒品：海洋天然产物为候选毒品。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In recent years, marine natural product bioprospecting has yielded a considerable number of drug candidates. Most of these molecules are still in preclinical or early clinical development but some are already on the market, such as cytarabine, or are predicted to be approved soon, such as ET743 (Yondelis). Research into the ecology of marine natural products has shown that many of these compounds function as chemical weapons and have evolved into highly potent inhibitors of physiological processes in the prey, predators or competitors of the marine organisms that use them. Some of the natural products isolated from marine invertebrates have been shown to be, or are suspected to be, of microbial origin and this is now thought to be the case for the majority of such molecules. Marine microorganisms, whose immense genetic and biochemical diversity is only beginning to be appreciated, look likely to become a rich source of novel chemical entities for the discovery of more effective drugs.
机译：近年来，海洋天然产物的生物勘探已经产生了大量的候选药物。这些分子中的大多数仍处于临床前或早期临床开发中，但一些已经在市场上出售，例如阿糖胞苷，或预计很快将被批准，例如ET743（Yondelis）。对海洋天然产物生态学的研究表明，这些化合物中的许多都起着化学武器的作用，并已发展成为使用它们的海洋生物的猎物，掠食者或竞争者中生理过程的高效抑制剂。从海洋无脊椎动物中分离出的某些天然产物已显示或怀疑是微生物起源的，现在认为大多数此类分子都是这种情况。海洋微生物的巨大遗传和生化多样性才刚刚开始被人们所认识，它看起来很可能成为发现更有效药物的新颖化学实体的丰富来源。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号