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首页> 外文期刊>Drug discovery today >Dendritic-cell-derived osteoclasts: a new game changer in bone-resorption-associated diseases
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Dendritic-cell-derived osteoclasts: a new game changer in bone-resorption-associated diseases

机译：树突细胞衍生的破骨细胞：骨吸收相关疾病的新游戏改变者

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摘要

Bone-resorbing cells, osteoclasts (OCs), and antigen-presenting cells, dendritic cells (DCs), share several features. They are derived from a common hematopoietic precursor, exhibit phagocytic activities and their functions are dependent upon receptor activator of nuclear factor KB ligand (RANKL). Upon inflammatory conditions, DCs can transdifferentiate toward functional OCs in the presence of RANKL. It has then been assumed that the increase in proinflammatory cytokines could provide a supportive environment for this transdifferentiation. In this review, we emphasize the molecular mechanisms underlying the potential for DCs to give rise to resorbing OCs in the context of bone-destruction associated diseases upon inflammatory conditions. Whether these mechanisms reveal new strategies for the discovery of therapeutic targets and drugs is discussed extensively.
机译：骨吸收细胞，破骨细胞（OCs）和抗原呈递细胞，树突状细胞（DC）具有多个特征。它们衍生自常见的造血前体，具有吞噬活性，其功能取决于核因子KB配体（RANKL）的受体激活剂。在炎症条件下，DC可以在存在RANKL的情况下向功能性OC分化。可以认为，促炎细胞因子的增加可以为这种转分化提供支持环境。在这篇综述中，我们强调了在炎症条件下与骨破坏相关疾病的背景下，DCs引起重吸收OCs的潜在分子机制。这些机制是否揭示了发现治疗靶标和药物的新策略，已得到广泛讨论。

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