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首页> 外文期刊>DMW: Deutsche Medizinische Wochenschrift >Faecal calprotectin: Less inappropriate endoscopies? - Measurement of calprotectin mostly does not replace endoscopy [F?kales Calprotectin: Weniger unn?tige Endoskopien? - Calprotectin-Bestimmung ersetzt Endoskopie in den meisten F?llen nicht]
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Faecal calprotectin: Less inappropriate endoscopies? - Measurement of calprotectin mostly does not replace endoscopy [F?kales Calprotectin: Weniger unn?tige Endoskopien? - Calprotectin-Bestimmung ersetzt Endoskopie in den meisten F?llen nicht]

机译：粪便钙卫蛋白：减少不适当的内窥镜检查？ -钙卫蛋白的测量大多不能代替内窥镜检查[粪钙卫蛋白：不必要的内镜检查较少吗？ -在大多数情况下，钙卫蛋白的测定不能代替内窥镜检查]

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Background. Natural killer (NK) cells are an integral part of the innate immune system. They have been suggested to play an important role in both defense against viral hepatitis and the pathogenesis of other liver diseases.Methods. NK cells from 134 individuals including patients with acute hepatitis B and C as well as chronic hepatitis B, C, and delta (D) patients were studied.Results. Infection with viral hepatitis was associated with increased frequencies of NK cells in the peripheral blood; that NK cells showed a less activated phenotype and were compromised in cytolotytic function and cytokine production in all viral hepatitis infections: Hepatitis virus infections did not alter NK cell differentiation, and the activity and severity of liver disease were reflected by alterations of NK cell surface receptors as demonstrated by principal component analysis.Conclusion. NK cell phenotypic and functional alterations can equally be observed in HBV, HCV, and HDV infections. Instead, patterns of NK cell alterations differ in acute and chronic infections. Thus, our data suggest a common mechanism in the alteration of NK cell phenotype and function with unique variations that depend on disease activity rather than virus-specific factors.
机译：背景。自然杀伤（NK）细胞是先天免疫系统不可或缺的一部分。已经表明它们在防御病毒性肝炎和其他肝脏疾病的发病机理中都起着重要作用。研究了134位个体的NK细胞，包括急性乙型和丙型肝炎患者以及慢性乙型，丙型肝炎和三角洲（D）患者。病毒性肝炎的感染与外周血NK细胞频率增加有关。在所有病毒性肝炎感染中，NK细胞表现出较少的激活表型，并在胞质功能和细胞因子产生方面受到损害：肝炎病毒感染并未改变NK细胞的分化，而NK细胞表面受体的改变反映了肝病的活性和严重程度如主成分分析所示。结论。在HBV，HCV和HDV感染中，同样可以观察到NK细胞的表型和功能改变。相反，NK细胞改变的模式在急性和慢性感染中有所不同。因此，我们的数据表明，NK细胞表型和功能改变的共同机制是取决于疾病活动而不是病毒特异性因素的独特变异。

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