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首页> 外文期刊>DMW: Deutsche Medizinische Wochenschrift >Invasive pneumococcal disease in Germany in the era of pneumococcal conjugate vaccination [Invasive Pneumokokken-Erkrankungen in Deutschland im Zeitalter der Pneumokokken-Konjugat-Impfung]
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Invasive pneumococcal disease in Germany in the era of pneumococcal conjugate vaccination [Invasive Pneumokokken-Erkrankungen in Deutschland im Zeitalter der Pneumokokken-Konjugat-Impfung]

机译：肺炎球菌结合疫苗接种时代的德国侵袭性肺炎球菌病[肺炎球菌结合疫苗接种时代的德国侵袭性肺炎球菌疾病]

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摘要

Background: Pneumococci remain a major cause of bacterial pneumonia, sepsis and meningitis globally. Methods: The German National Reference Center for Streptococci at the Institute for Medical Microbiology of the University Hospital RWTH Aachen, Germany, has carried out surveillance studies on invasive pneumococcal disease (IPD) since 1992. This report is based on IPD-cases from adults and children, received between July 1992 and June 2013 and July 1997 and June 2013 respectively. Results: From 1997-2006 the proportion of infections among children ≤23 months of age with serotypes included in the 7-valent vaccine was about 65%. Since the start of childhood vaccination in 2006 the percentage has continuously decreased, reaching <5% in 2012/2013. Also among adults, for whom conjugate vaccination was not indicated, this percentage decreased from 40-45% in 1992-2006 to about 8% in 2012/2013. This phenomenon is denoted as herd protection. The resistance rate against Penicillin G remained under 4% among children and under 2.5% among adults over the whole study period. Since 2005/2006 macrolide resistance levels have decreased to about 5% among children and 8% among adults. Conclusion: The continuous decrease of vaccine serotypes as well as the decreasing IPD incidence since the beginning of childhood vaccination document the success of pneumococcal conjugate vaccination.
机译：背景：肺炎球菌仍然是全球细菌性肺炎，败血症和脑膜炎的主要原因。方法：自1992年以来，德国亚琛大学附属医院医学微生物研究所的德国国家链球菌参考中心已对侵袭性肺炎球菌疾病（IPD）进行了监测研究。本报告基于成人和成人的IPD病例分别于1992年7月至2013年6月，1997年7月和2013年6月收到的儿童。结果：从1997年至2006年，在7价疫苗中，血清型≤23个月的儿童中的感染比例约为65％。自2006年开始进行儿童疫苗接种以来，这一百分比持续下降，在2012/2013年达到<5％。同样在未接种共轭疫苗的成年人中，这一百分比从1992-2006年的40-45％降至2012/2013年的8％。这种现象称为牧群保护。在整个研究期间，儿童对青霉素G的耐药率保持在4％以下，成年人对2.5％以下。自2005/2006年以来，儿童对大环内酯类药物的耐药性水平已降至5％左右，而成年人则为8％。结论：自从儿童接种疫苗以来，疫苗血清型的持续减少以及IPD发病率的降低证明了肺炎球菌结合疫苗的成功接种。

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