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首页> 外文期刊>DNA and Cell Biology >Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population.
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Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population.

机译：白细胞介素（IL）-12和IL-27基因多态性与中国人群慢性阻塞性肺疾病的关系。

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The pathogenesis of chronic obstructive pulmonary disease (COPD) is not fully understood, and environment and genetic factors have been investigated. Moreover, cytokine genes play an important role in COPD pathogenesis. However, the molecular mechanism of COPD induced by the factors is still unknown. The present study was undertaken to clarify a role of interleukin (IL)-12 16974A/C and IL-27 4730T/C, -964A/G, and 2905T/G polymorphisms in Chinese subjects with COPD. Polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) and sequence analyses were used to type IL-12 and IL-27 polymorphisms in 120 patients with COPD and 100 healthy controls. There were significant differences in the genotype and allele distribution of -964A/G and 2905T/G polymorphisms of the IL-27 gene among cases and controls in a Chinese population. When compared with the control group, subjects with AG genotype of the IL-27 -964A/G had a 2.22-fold decreased risk of COPD (odds ratio [OR] = 0.450, 95% confidence interval [CI]: 0.245-0.826; p = 0.009), and subjects with TG genotype of the IL-27 2905T/G had a 2.85-fold decreased risk of COPD (OR = 0.351, 95% CI: 0.137-0.899; p = 0.024). Compared with the TAT haplotype, the TGG haplotype was associated with a significantly decreased risk of COPD (OR = 0.29, 95% CI: 0.108-0.784; p = 0.010). Even after Bonferroni corrections, significant associations with COPD were observed for the AG genotype of the IL-27 -964A/G and the TGG haplotype of the IL-27 gene. Our data suggest that polymorphisms in the IL-27 gene may play a role in the development of COPD in Chinese population.
机译：慢性阻塞性肺疾病（COPD）的发病机理尚未完全了解，并且已经研究了环境和遗传因素。此外，细胞因子基因在COPD发病机理中起重要作用。然而，由这些因素诱导的COPD的分子机制仍是未知的。进行本研究以阐明白细胞介素（IL）-12 16974A / C和IL-27 4730T / C，-964A / G和2905T / G多态性在中国COPD受试者中的作用。聚合酶链反应/限制性片段长度多态性（PCR / RFLP）和序列分析用于120例COPD患者和100例健康对照者的IL-12和IL-27型多态性。在中国人群中，病例和对照中IL-27基因的-964A / G和2905T / G多态性的基因型和等位基因分布存在显着差异。与对照组相比，AG基因型为IL-27 -964A / G的受试者患COPD的风险降低了2.22倍（几率[OR] = 0.450，95％置信区间[CI]：0.245-0.826; p = 0.009），而TG基因型为IL-27 2905T / G的受试者发生COPD的风险降低了2.85倍（OR = 0.351，95％CI：0.137-0.899; p = 0.024）。与TAT单倍型相比，TGG单倍型与COPD风险显着降低有关（OR = 0.29，95％CI：0.108-0.784; p = 0.010）。即使在Bonferroni校正后，IL-27 -964A / G的AG基因型和IL-27基因的TGG单倍型仍与COPD显着相关。我们的数据表明，IL-27基因的多态性可能在中国人群COPD的发生中起作用。

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