Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin

Neznanov N; Kondratova A; Chumakov KM; Neznanova L; Kondratov R; Banerjee AK; Gudkov AV

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Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin

机译：槲皮素酶pirin使脊髓灰质炎病毒复制抵抗类黄酮槲皮素

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Flavonoid quercetin and its derivative, methylquercetin, inhibit the replication of poliovirus in several cell lines. Here, we show that replication of poliovirus is inhibited by quercetin and that the extent of this inhibition depends on the intracellular content of pirin, a quercetinase. HeLa cells contain higher content of pirin protein than normal kidney human epithelial (NKE) or 293 cells do. Poliovirus replication in HeLa cells is significantly more resistant to quercetin than its replication in NKE and 293 cells. Overexpression of pirin reduced antiviral inhibitory effect of quercetin, while siRNA-induced suppression of pirin level made poliovirus replication more sensitive to the flavonoid. The results suggest that quercetinase activity of pirin determines the resistance of poliovirus infection to quercetin.

机译：类黄酮槲皮素及其衍生物甲基槲皮素可抑制脊髓灰质炎病毒在几种细胞系中的复制。在这里，我们显示脊髓灰质炎病毒的复制受到槲皮素的抑制，并且这种抑制的程度取决于pirin（一种槲皮素酶）的细胞内含量。 HeLa细胞比正常的肾人类上皮细胞（NKE）或293细胞含有更高的pirin蛋白含量。与在NKE和293细胞中复制相比，HeLa细胞中的脊髓灰质炎病毒复制对槲皮素的抵抗力明显更高。 pirin的过表达降低了槲皮素的抗病毒抑制作用，而siRNA诱导的pirin水平抑制使脊髓灰质炎病毒复制对类黄酮更为敏感。结果表明，pirin的槲皮素酶活性决定了脊髓灰质炎病毒感染对槲皮素的抵抗力。

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来源
《DNA and Cell Biology》 |2008年第4期|共8页
作者
Neznanov N; Kondratova A; Chumakov KM; Neznanova L; Kondratov R; Banerjee AK; Gudkov AV;
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正文语种 eng
中图分类生物化学;
关键词
IN-VIVO METABOLITES; PROTEIN-SYNTHESIS; NUCLEAR-PROTEIN; RNA-SYNTHESIS; BREFELDIN-A; KINASE-B; INHIBITION; 3-KINASE; INITIATION; 3-METHYLQUERCETIN;

机译：体内代谢产物;蛋白质合成;核蛋白;RNA合成;BREFELDIN-A;激酶B;抑制;3-激酶;起始;3-甲基槲皮素;

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专利

1. Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin [J] . Neznanov N, Kondratova A, Chumakov KM, DNA and Cell Biology . 2008,第4期

机译：槲皮素酶pirin使脊髓灰质炎病毒复制抵抗类黄酮槲皮素
2. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. [J] . OLeary KA, Day AJ, Needs PW, Biochemical Pharmacology . 2003,第3期

机译：体外肝脏模型对槲皮素7-和槲皮素3-葡萄糖醛酸的代谢：人类β-葡萄糖醛酸苷酶，磺基转移酶，儿茶酚-O-甲基转移酶和多抗性蛋白2（MRP2）在类黄酮代谢中的作用。
3. Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase C|[alpha]| [J] . Maria Russo, Rosanna Palumbo, Annalisa Mupo, Oncogene . 2003,第21期

机译：类黄酮槲皮素通过激活蛋白激酶C |α|使CD95耐药细胞系对细胞凋亡敏感。
4. Functionalization of Flavonoids (Quercetin) to Chitosan Matrix and Determination of Antioxidant Activity of Obtained Bio-composites [C] . M. Gonta, E. Sirbu, S. Robu International Conference on Nanotechnologies and Biomedical Engineering . 2020

机译：黄酮类化合物（槲皮素）对壳聚糖基质的官能化和获得的生物复合材料的抗氧化活性的测定
5. Studies on antioxidant activity of flavonoids quercetin, keampferol, geneistein, and glutathione in proteins and 3T3-LA1 cells. [D] . Lo, Andrew M. 2014

机译：研究类黄酮槲皮素，keampferol，染料木黄酮和谷胱甘肽在蛋白质和3T3-LA1细胞中的抗氧化活性。
6. Synergistic Effect of the Flavonoid Catechin Quercetin or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole [O] . Cecília Rocha da Silva, João Batista de Andrade Neto, Rosana de Sousa Campos, 2014

机译：类黄酮儿茶素槲皮素或表没食子儿茶素没食子酸酯与氟康唑的协同作用诱导耐氟康唑的热带念珠菌凋亡。
7. Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα [O] . Maria Russo, Rosanna Palumbo, Annalisa Mupo, 2003

机译：黄酮类槲皮素通过激活蛋白激酶Cα来敏化CD95抗性细胞系至细胞凋亡

Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin

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