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首页> 外文期刊>DNA and Cell Biology >Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population.
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Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population.

机译：极光A基因的多态性与土耳其人群的肺癌无关。

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摘要

Lung cancer, a complex neoplasm of lung tissue, is influenced by several environmental and genetic factors which could be changed in each individual. Aurora-A gene is related to mitotic events such as: chromosome instability, cell cycle regulation, spindle formation, and kinetechore-microtubule connections. This centrosomic serine/threonine kinase provides a strong connection between mitotic errors and carcinogenesis. The genomic alterations such as single nucleotide polymorphisms (SNPs) can exist in molecular pathways of lung cancer. Therefore, we evaluated the role of genetic polymorphisms of Aurora-A gene in the lung cancer in the Turkish population. Genotypes of five Aurora-A polymorphisms (F31I, V57I, 6328G/A, P50L, and S104L) were determined in 102 healty controls and 102 new diagnosed lung cancer cases. All samples were genotyped with DNA sequence technique. There were not any genotype variations in P50L, S104L, and 6328G/A polymorphisms. The frequencies of both genotypes F31I and V57I in lung cancer patients were not significantly different from those in controls (p 0.05). A multivariable logistic regression analysis including patient characteristics, such as age and gender, did not change the results.
机译：肺癌是一种复杂的肺组织肿瘤，受到几种环境和遗传因素的影响，这些因素可能会因个体而异。 Aurora-A基因与有丝分裂事件有关，例如：染色体不稳定，细胞周期调节，纺锤体形成以及运动技术与微管的连接。该中心体丝氨酸/苏氨酸激酶在有丝分裂错误和致癌作用之间提供了强有力的联系。诸如单核苷酸多态性（SNP）的基因组改变可以存在于肺癌的分子途径中。因此，我们评估了Aurora-A基因遗传多态性在土耳其人群肺癌中的作用。在102例健康对照和102例新诊断的肺癌病例中确定了5个Aurora-A多态性的基因型（F31I，V57I，6328G / A，P50L和S104L）。用DNA序列技术对所有样品进行基因分型。 P50L，S104L和6328G / A多态性没有任何基因型变异。肺癌患者的两种基因型F31I和V57I的频率与对照组相比无显着差异（p> 0.05）。包括患者特征（例如年龄和性别）的多变量逻辑回归分析并未改变结果。

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