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首页> 外文期刊>Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology >Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis
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Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis

机译：线虫秀丽隐杆线虫对致病性苏云金芽孢杆菌的蛋白质组和转录组反应的重叠和独特特征

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Pathogen infection can activate multiple signaling cascades that ultimately alter the abundance of molecules in cells. This change can be measured both at the transcript and protein level. Studies analyzing the immune response at both levels are, however, rare. Here, we compare transcriptome and proteome data generated after infection of the nematode and model organism Caenorhabditis elegans with the Gram-positive pathogen Bacillus thuringiensis. Our analysis revealed a high overlap between abundance changes of corresponding transcripts and gene products, especially for genes encoding C-type lectin domain-containing proteins, indicating their particular role in worm immunity. We additionally identified a unique signature at the proteome level, suggesting that the C. elegans response to infection is shaped by changes beyond transcription. Such effects appear to be influenced by AMP-activated protein kinases (AMPKs), which may thus represent previously unknown regulators of C. elegans immune defense. (C) 2015 The Authors. Published by Elsevier Ltd.
机译：病原体感染可以激活多个信号级联，最终改变细胞中分子的丰度。可以在转录本和蛋白质水平上测量此变化。然而，在两个水平上分析免疫应答的研究很少。在这里，我们比较了线虫和模型生物秀丽隐杆线虫感染革兰氏阳性病原菌苏云金芽孢杆菌后产生的转录组和蛋白质组数据。我们的分析显示，相应转录本和基因产物的丰度变化之间存在高度重叠，尤其是对于编码C型含凝集素结构域的蛋白质的基因，这表明它们在蠕虫免疫中的特殊作用。我们还在蛋白质组水平上确定了独特的特征，这表明秀丽隐杆线虫对感染的反应受转录以外的变化影响。这种作用似乎受到AMP激活的蛋白激酶（AMPK）的影响，因此可能代表线虫免疫防御的未知调节子。 （C）2015作者。由Elsevier Ltd.发布

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