...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drugs of today: Medicamentos de actualidad >CEREBROLYSIN IMPROVES SYMPTOMS AND DELAYS PROGRESSION IN PATIENTS WITH ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA
【24h】

CEREBROLYSIN IMPROVES SYMPTOMS AND DELAYS PROGRESSION IN PATIENTS WITH ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA

机译：脑溶血素改善阿尔茨海默氏病和血管性痴呆患者的症状并延缓其进展

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dementia is the result of various cerebral disorders, leading to an acquired loss of memory and impaired cognitive ability. The most common forms are Alzheimer's disease (AD) and vascular dementia (VaD). Neurotrophic factors are essential for the survival and differentiation of developing neurons and protecting them against damage under pathologic conditions. Cerebrolysin is a peptide preparation that mimics the pleiotropic effects of neurotrophic fac-tors. Several clinical trials investigating the therapeutic efficacy of Cerebrolysin in AD and VaD have confirmed the proof of concept. The results of these trials have shown statistically significant and clinically relevant treatment effects of Cerebrolysin on cognitive, global and functional domains in mild to moderately severe stages of dementia. Doses of 10 and 30 mL were the most effective, but higher doses of up to 60 mL turned out to be most effective in improving neuropsychiatric symptoms, which become relevant at later stages of the disease. Combining treatment with cholinesterase inhibitors and Cerebrolysin indicated long-term synergistic treatment effects in mild to moderate AD. The efficacy of Cerebrolysin persisted for up to sev-
机译：痴呆症是各种脑部疾病的结果，导致获得性记忆丧失和认知能力受损。最常见的形式是阿尔茨海默氏病（AD）和血管性痴呆（VaD）。神经营养因子对于发育中的神经元的存活和分化以及在病理条件下保护其免受损害至关重要。脑溶素是模拟神经营养因子的多效作用的肽制剂。几项研究脑溶素在AD和VaD中的疗效的临床试验已证实了这一概念的证明。这些试验的结果表明，脑溶素对轻度至中度重度痴呆患者的认知，整体和功能结构域具有统计学意义和临床相关的治疗作用。 10和30毫升的剂量是最有效的，但最高剂量达到60毫升的剂量对改善神经精神症状最有效，而神经精神症状在疾病的后期阶段就变得重要了。与胆碱酯酶抑制剂和脑溶血素联合治疗表明在轻度至中度AD中具有长期协同治疗作用。脑溶素的疗效持续多达七年。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号