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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Sugammadex, the first selective relaxant binding agent for neuromuscular block reversal.
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Sugammadex, the first selective relaxant binding agent for neuromuscular block reversal.

机译：Sugammadex，第一种用于神经肌肉阻滞逆转的选择性松弛剂。

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摘要

Neuromuscular blocking agents (NMBAs) are widely used to provide muscle relaxation for endotracheal intubation, certain modes of mechanical ventilation and surgical procedures. Full and rapid reversal of this muscle relaxation is needed to prevent residual muscle paralysis and respiratory compromise. The novel selective reversal binding agent, sugammadex, rapidly reverses muscle paralysis from steroidal NMBAs. Sugammadex encapsulates steroidal NMBAs in the plasma and renders them unavailable to the neuromuscular junction receptors. Unlike other reversal agents, sugammadex has the ability to provide fast and thorough reversal of neuromuscular paralysis regardless of the level of blockade. Sugammadex has shown limited adverse effects and avoids the cardiovascular and autonomic effects commonly seen with the conventional reversal of NMBAs (anticholinesterase plus anticholinergic). This review summarizes the current knowledge about sugammadex, its pharmacology and safety profile, dosing recommendations, potential clinical applications and economic impact.
机译：神经肌肉阻滞剂（NMBA）被广泛用于为气管插管，某些形式的机械通气和手术程序提供肌肉松弛。为了防止残留的肌肉麻痹和呼吸系统受损，需要完全快速地逆转这种肌肉松弛。新型选择性逆转结合剂sugammadex可快速逆转甾族NMBA引起的肌肉麻痹。 Sugammadex将类固醇NMBA包裹在血浆中，使神经肌肉接头受体无法使用它们。与其他逆转剂不同，sugammadex具有提供快速彻底的神经肌肉麻痹逆转的能力，而与阻断水平无关。 Sugammadex已显示出有限的不良反应，并且避免了常规NMBA逆转（抗胆碱酯酶加抗胆碱能药）常见的心血管和自主神经作用。这篇综述总结了有关sugammadex的当前知识，其药理学和安全性概况，给药建议，潜在的临床应用和经济影响。

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