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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Projections for insulin treatment for diabetics.
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Projections for insulin treatment for diabetics.

机译：糖尿病患者胰岛素治疗的投影。

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摘要

The evolution of insulin treatment of diabetes has dramatically changed the natural course of this disease. Modern recombinant DNA technology has brought about many new insulin analogues with improved pharmacokinetics, resulting in better glycemic control. In addition, improved insulin delivery systems, such as insulin pumps and pens, have been introduced to provide convenience and to enhance patient compliance. Efforts are currently being devoted to developing noninvasive insulin formulations, such as oral and pulmonary insulin. A number of products are at different stages of clinical trials. Meanwhile, the quest for a permanent cure for diabetes continues. The frontier of diabetes research has gone through a period of substantial expansion, with the emergence of new areas that include gene therapy, islet cell transplantation and diabetic vaccine. Technological breakthroughs, such as recombinant DNA, nanotechnology, microarray-aided genomics and proteomics, will provide more profound insights into thepathogenesis, and the immunological and biological basis of diabetes. Our growing knowledge in these areas will ultimately contribute to the discovery of preventive methods against or a cure for this disease.
机译：胰岛素治疗糖尿病的发展已大大改变了这种疾病的自然过程。现代重组DNA技术带来了许多具有改善的药代动力学的新胰岛素类似物，从而实现了更好的血糖控制。另外，已经引入了改进的胰岛素输送系统，例如胰岛素泵和笔，以提供便利并增强患者依从性。当前致力于开发无创胰岛素制剂，例如口服和肺胰岛素。许多产品处于临床试验的不同阶段。同时，寻求永久治愈糖尿病的要求仍在继续。随着基因治疗，胰岛细胞移植和糖尿病疫苗等新领域的出现，糖尿病研究的前沿已经历了一个实质性扩展。重组DNA，纳米技术，微阵列辅助的基因组学和蛋白质组学等技术突破将为糖尿病的发病机理以及免疫和生物学基础提供更深刻的见解。我们在这些领域的不断增长的知识最终将有助于发现预防或治愈该疾病的方法。

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