...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Oral lichen planus: an update.
【24h】

Oral lichen planus: an update.

机译：口腔扁平苔藓：更新。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Oral lichen planus (OLP) is a chronic autoimmune disease of unknown etiology that affects the skin and mucosae, including the oral cavity. The disease is characterized by lacy, thin white lines on a violaceous background on the oral mucosa, usually on the inside of the cheeks. The disease is also characterized by chronic inflammation and is often associated with severe pain and a burning sensation in the mouth. The etiopathogenesis of lichen planus is complex, with the involvement of T lymphocytes, mast cells, intercellular adhesion molecule-1 (ICAM-1) and major histocompatibility complex class II antigens. The immunologic process results in vacuolar degeneration, lysis of basal cells and, ultimately, liquefaction of the basal cells. The precipitating factors of OLP can be: stress, particular foods, dental plaque, systemic illness and poor oral hygiene. Often no medication is necessary for benign disease. In the case of severe pain and the burning sensation, high potency topical corticosteroids remain the most reliably effective treatment. Other available treatments are topical cyclosporine, tacrolimus, retinoids and other immunosuppressive agents. Systemic corticosteroids may be indicated in patients whose condition is unresponsive to topical corticosteroids. However, OLP remains a challenging disease to treat, in spite of the numerous treatments tried in the patient population.
机译：口腔扁平苔藓（OLP）是一种病因不明的慢性自身免疫性疾病，会影响皮肤和粘膜（包括口腔）。该病的特征是在口腔粘膜上通常位于脸颊内侧的蕾丝状白色细线。该疾病还具有慢性炎症的特征，并且通常与剧烈疼痛和口腔灼热感相关。扁平苔藓的病因复杂，涉及T淋巴细胞，肥大细胞，细胞间粘附分子1（ICAM-1）和主要的组织相容性II类复杂抗原。免疫过程导致液泡变性，基底细胞溶解，并最终导致基底细胞液化。 OLP的诱发因素可能是：压力，特殊食物，牙菌斑，全身性疾病和不良口腔卫生。对于良性疾病，通常不需要药物。在剧烈疼痛和灼热感的情况下，高效外用糖皮质激素仍然是最可靠的有效治疗方法。其他可用的治疗方法是局部用环孢素，他克莫司，类维生素A和其他免疫抑制剂。病情对局部皮质类固醇无反应的患者可使用全身性皮质类固醇。然而，尽管在患者人群中尝试了多种治疗方法，但OLP仍然是一种具有挑战性的疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号