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Aspirin for the primary prevention of cardiovascular events.

机译:阿司匹林用于心血管事件的一级预防。

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摘要

There is significant evidence that low-dose aspirin is effective in preventing the first myocardial infarction in men and ischemic stroke in women. There is also an increased risk for major gastrointestinal tract hemorrhage and a suggestive, but nonsignificant, increase in the risk for hemorrhagic stroke. If there is a history of ulcer disease or upper-gastrointestinal tract bleeding, Helicobacter pylori should be eradicated (if present) and a proton pump inhibitor used with aspirin therapy. In conclusion, the benefits of low-dose aspirin (75-162 mg/day) in the prevention of myocardial infarction in men and thrombotic stroke in women generally outweigh the risks of serious bleeding in adults with a coronary heart disease risk >1% per year or >1% in 10 years.
机译:有大量证据表明,小剂量阿司匹林可有效预防男性的首次心肌梗塞和女性的缺血性中风。发生重大胃肠道出血的风险也增加,并且出血性中风的风险提示但无明显意义的增加。如果有溃疡病史或上消化道出血史,应根除幽门螺杆菌(如果有),并使用阿司匹林治疗的质子泵抑制剂。总之,低剂量阿司匹林(75-162 mg /天)预防男性心肌梗塞和女性血栓性中风的益处通常超过成年人严重出血的危险,而冠心病的危险性> 1%年或10年内> 1%。

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