...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Psychopathology of depression.
【24h】

Psychopathology of depression.

机译：抑郁症的心理病理学。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This review assesses some of the important advances that have been made in our understanding of the psychopathology of depression. While the monoamine theory, that postulates dysfunctional noradrenergic and serotonergic systems as the underlying cause of depression, has been valuable in the development of conventional antidepressants that are thought to act by reversing these dysfunctional states, recent clinical and experimental studies have questioned this reductionist view of depression. This has led to an assessment of the role of dysfunctional endocrine and immune systems in the aetiology of depression. In addition to explaining the link between defective neurotransmitter function and the symptoms of depression, changes in the endocrine and immune axes also help to explain the link between major depression and physical ill health. In addition, experimental and clinical studies have extended the possible involvement of neurotransmitters to include the glutamate and GABA systems. Such approaches maystimulate the development of new types of antidepressants that hopefully will combine increased efficacy with shorter speed of onset and improved side effect profiles. (c) 2007 Prous Science. All rights reserved.
机译：这篇综述评估了我们对抑郁症的心理病理学理解方面取得的一些重要进展。虽然认为单胺理论认为功能失调的去甲肾上腺素能和血清素能系统是抑郁的根本原因，但在开发常规抗抑郁药方面很有价值，而传统的抗抑郁药被认为可以通过逆转这些功能失调的状态来起作用，但是最近的临床和实验研究对这种还原性观点提出了质疑。萧条。这导致对功能失调的内分泌和免疫系统在抑郁症病因中的作用进行了评估。除了解释神经递质功能受损与抑郁症状之间的联系外，内分泌和免疫轴的变化也有助于解释严重抑郁与身体不适之间的联系。另外，实验和临床研究已经扩展了神经递质的可能涉及范围，包括谷氨酸和GABA系统。此类方法可能会刺激新型抗抑郁药的开发，有望将提高的疗效与更短的发作速度和改善的副作用相结合。 （c）2007 Prous科学。版权所有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号