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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >EXPLORING THE ROLE OF DONEPEZIL IN DEMENTIA WITH LEWY BODIES
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EXPLORING THE ROLE OF DONEPEZIL IN DEMENTIA WITH LEWY BODIES

机译：利沃夫病探索多奈哌齐在痴呆症中的作用

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摘要

Dementia with Lewy bodies (DLB) is considered the second most common form of dementia in the elderly. The cognitive fluctuations, hallucinations and extrapyramidal symptoms and signs suggest simultaneous neurodegeneration in multiple neuronal pathways including both dopaminergic and cholinergic transmission. In the past few years, several small studies have demonstrated the benefit of acetylcholinesterase inhibitors (AChEIs) on the cognitive and behavioral symptoms of DLB. These drugs, by reversibly blocking the hydrolytic activity of AChE, increase the availability of synaptic acetylcholine. Neuropathological and neuroimaging studies demonstrated that cholinergic neurotransmission is more defective in DLB than in Alzheimer's disease (AD). Despite the relevance of AChEIs to DLB, there are no FDA-approved drugs for its management. The aim of this review is to summarize the literature on the application of donepezil in DLB. Although the results are inconclusive, when one compares and contrasts them to the results of the AD-donepezil trials, the effect size appears larger. Placebo-controlled, randomized, well-powered studies of adequate length are needed to avoid underutilization of a potentially efficacious drug.
机译：路易体痴呆（DLB）被认为是老年人中第二大最常见的痴呆形式。认知波动，幻觉和锥体束外症状和体征表明，在包括多巴胺能和胆碱能传递在内的多种神经元途径中神经元同时变性。在过去的几年中，一些小型研究证明了乙酰胆碱酯酶抑制剂（AChEIs）对DLB的认知和行为症状的益处。这些药物通过可逆地阻断AChE的水解活性，增加了突触乙酰胆碱的利用率。神经病理学和神经影像学研究表明，胆碱能神经传递在DLB中比在阿尔茨海默氏病（AD）中更具缺陷。尽管AChEIs与DLB相关，但尚无FDA批准的药物用于其管理。这篇综述的目的是总结关于多奈哌齐在DLB中的应用的文献。尽管结果尚无定论，但当将其与AD-多奈哌齐试验的结果进行比较和对比时，其效果似乎更大。需要进行足够长的安慰剂对照，随机，有力的研究，以避免潜在有效药物的未充分利用。

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