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Atomoxetine - treatment of attention deficit hyperactivity disorder: beyond stimulants.

机译:Atomoxetine-注意缺陷多动障碍的治疗:兴奋剂以外。

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Among the pharmacotherapeutic interventions for attention deficit hyperactivity disorder (ADHD), psychostimulants have been the drugs of choice for many years. However, some patients do not adequately respond to or cannot tolerate stimulant treatment. Among nonstimulants for ADHD, the most extensively studied and the only one approved for use in the United States is the norepinephrine reuptake inhibitor atomoxetine. This paper reviews atomoxetine's chemistry and putative mechanism of action, as well as its clinical pharmacokinetics, metabolism, and efficacy and safety in acute clinical trials. (c) 2004 Prous Science. All rights reserved.
机译:在针对注意力缺陷多动障碍(ADHD)的药物治疗干预措施中,精神刺激药已成为多年的首选药物。但是,有些患者对兴奋剂治疗反应不足或不能耐受。在用于ADHD的非兴奋剂中,最广泛研究且在美国唯一被批准使用的是去甲肾上腺素再摄取抑制剂阿莫西汀。本文综述了阿托西汀的化学和假定的作用机理,及其在急性临床试验中的临床药代动力学,代谢以及疗效和安全性。 (c)2004 Prous科学。版权所有。

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