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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Rosiglitazone maleate/metformin hydrochloride: a new formulation therapy for type 2 diabetes.
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Rosiglitazone maleate/metformin hydrochloride: a new formulation therapy for type 2 diabetes.

机译：罗格列酮马来酸酯/盐酸二甲双胍：一种用于2型糖尿病的新制剂疗法。

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Many patients with type 2 diabetes require treatment with more than one antihyperglycemic drug to achieve optimal glycemic control. The thiazolidinediones are a novel class of oral antihyperglycemic drugs that improve glycemic control primarily by increasing peripheral insulin resistance and sensitizing the skeletal muscle, liver and adipose tissue to the actions of insulin, in addition to improving beta-cell function. One of the many features of the thiazolidinedione class of drugs is their synergism with other antihyperglycemic drugs that have a different mechanism of action. The combination of metformin hydrochloride, a biguanide that enhances glucose uptake in peripheral tissues and reduces hepatic gluconeogenesis, with rosiglitazone maleate, one of the newly available members of the thiazolidinedione family, offers a rational therapeutic approach to the treatment of type 2 diabetes. In patients whose type 2 diabetes is inadequately controlled with metformin monotherapy, the addition of rosiglitazone significantly improves glycemic control, insulin sensitivity and beta-cell function, compared with either drug alone. In addition, this combination therapy has beneficial effects on other cardiovascular risk factors. Rosiglitazone maleate/metformin hydrochloride combination therapy is well tolerated in patients with type 2 diabetes and has a favorable safety profile. This review summarizes the available evidence on the clinical efficacy and safety of rosiglitazone maleate and metformin hydrochloride combination therapy in patients with type 2 diabetes.
机译：许多2型糖尿病患者需要使用一种以上的降血糖药物进行治疗，以实现最佳的血糖控制。噻唑烷二酮是一类新型的口服降血糖药，除改善β细胞功能外，其主要通过增加外周胰岛素抵抗并使骨骼肌，肝脏和脂肪组织对胰岛素的作用而改善血糖控制。噻唑烷二酮类药物的许多特征之一是它们与其他具有不同作用机理的降血糖药的协同作用。盐酸二甲双胍（一种双胍类药物，可增强周围组织的葡萄糖吸收并减少肝糖异生）与噻唑烷二酮家族新成员之一的马来酸罗格列酮的组合，为治疗2型糖尿病提供了合理的治疗方法。与单独使用两种药物相比，在二甲双胍单药治疗不能充分控制2型糖尿病的患者中，添加罗格列酮显着改善了血糖控制，胰岛素敏感性和β细胞功能。此外，这种联合疗法对其他心血管危险因素也有有益作用。罗格列酮马来酸酯/盐酸二甲双胍联合治疗对2型糖尿病患者的耐受性良好，并且具有良好的安全性。这篇综述总结了罗格列酮马来酸酯和盐酸二甲双胍联合治疗2型糖尿病患者的临床疗效和安全性的现有证据。

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