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The promise of thalidomide: Evolving indications.

机译：沙利度胺的前景：不断发展的适应症。

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摘要

Thalidomide was first used in the late 1950s but it was withdrawn from the market in the 1960s for its notorious teratogenic effects. This drug was more recently rediscovered as a powerful immunomodulatory and antiinflammatory agent and was approved by the FDA in 1998 for treatment of erythema nodosum leprosum. Thalidomide has shown great promise in advanced or refractory multiple myeloma either alone or in combination with other agents. It has also demonstrated benefits in a wide variety of disparate conditions such as aphthous and genital ulcers, cancer cachexia, HIV, tuberculosis and chronic graft versus host disease. Thalidomide is being investigated for treatment of renal cell carcinoma, and liver and thyroid cancers. Better understanding of its many mechanisms of action has provoked great interest in its potential use for treatment of various disorders. This review focuses on thalidomide's mechanisms of action, biochemistry, pharmacokinetics and its use in erythema nodosum leprosum as well as multiple myeloma, graft versus host disease, and renal cell carcinoma. (c) 2004 Prous Science. All rights reserved.
机译：沙利度胺在1950年代后期首次使用，但由于其致畸作用而在1960年代退出市场。最近该药物被重新发现为一种强大的免疫调节和抗炎药，并于1998年被FDA批准用于治疗结节性红斑麻风病。沙利度胺在单独或与其他药物联合治疗晚期或难治性多发性骨髓瘤中显示出巨大的希望。在各种不同的情况下，例如口疮和生殖器溃疡，癌症恶病质，HIV，结核病以及慢性移植物抗宿主病，也证明了它的益处。沙利度胺正在研究用于治疗肾细胞癌以及肝癌和甲状腺癌的方法。对它的许多作用机制的更好的理解引起了人们对其潜在用途的各种治疗的极大兴趣。本文综述了沙利度胺的作用机理，生物化学，药代动力学及其在结节性红斑性麻风病以及多发性骨髓瘤，移植物抗宿主病和肾细胞癌中的应用。 （c）2004 Prous科学。版权所有。

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