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Systemic treatment of advanced non-small cell lung cancer.

机译：晚期非小细胞肺癌的全身治疗。

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摘要

Lung cancer, a highly lethal malignancy, is the leading cause of cancer-related mortality in the US, accounting for 28% of all deaths related to cancer. Non-small cell lung cancer comprises 80-85% of lung cancer diagnoses and includes the histologies of adenocarcinoma and its subtype bronchoalveolar carcinoma, squamous cell carcinoma and large cell carcinoma. This article reviews the use of cytotoxic chemotherapies and other systemic treatments for patients with advanced (metastatic and/or recurrent) non-small cell lung cancer. Despite great efforts, only minor gains have been made over the past decade in the treatment of advanced non-small cell lung cancer for patients with a good performance status in terms of prolonging survival and improving quality of life. Currently, the standard of treatment is a platinum-based doublet, with the second agent being selected contingent upon the comorbidities of the patient and the toxicity profile of the drug. The focus of clinical research is centered on the application of the use of targeted, molecularly directed therapies, likely used in combination with either cytotoxics and/or other novel targeted agents, in an attempt to improve the therapeutic ratio of systemic treatments for this large population. (c) 2004 Prous Science. All rights reserved.
机译：肺癌是一种高度致死性的恶性肿瘤，是美国癌症相关死亡率的主要原因，占所有与癌症相关死亡的28％。非小细胞肺癌占肺癌诊断的80-85％，包括腺癌及其亚型支气管肺泡癌，鳞状细胞癌和大细胞癌的组织学。本文综述了晚期（转移和/或复发）非小细胞肺癌患者使用细胞毒性化学疗法和其他全身治疗方法的情况。尽管付出了巨大的努力，但在过去的十年中，在延长生存期和改善生活质量方面，对处于良好状态的患者进行晚期非小细胞肺癌的治疗仅取得了很小的进展。当前，治疗的标准是基于铂的双联体，根据患者的合并症和药物的毒性情况选择第二种药物。临床研究的重点集中在可能与细胞毒素和/或其他新型靶向药物联合使用的靶向，分子定向疗法的应用上，以试图改善这一人群的全身治疗的治疗率。 （c）2004 Prous科学。版权所有。

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