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Inflammatory biomarkers and statins.

机译:炎性生物标志物和他汀类药物。

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The concept of atherosclerosis as an inflammatory disorder has led to the exploration of new pathogeneses of this disease. In this regard, the levels of several inflammatory molecules are frequently increased in subjects at high risk of developing an acute coronary event. With a simple analysis we can characterize the circulating levels of a marker and its therapeutic modulation with various drugs. In this review we have analyzed different inflammatory markers currently used, such as C-reactive protein (CRP), CD40 ligand, adhesion molecules and chemokines, and their possible modulation by therapeutic intervention with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Moreover, in the future, new technologies will allow us to discover new markers, or sets of them, that could indicate the direction to be taken in the prevention and treatment of cardiovascular diseases. (c) 2005 Prous Science. All rights reserved.
机译:动脉粥样硬化是一种炎症性疾病,这一概念促使人们对该疾病的新病原体进行了探索。在这方面,在具有发展为急性冠状动脉事件的高风险的受试者中,几种炎性分子的水平经常增加。通过简单的分析,我们可以表征标记物的循环水平及其对各种药物的治疗性调节。在这篇综述中,我们分析了目前使用的不同炎症标记物,例如C反应蛋白(CRP),CD40配体,粘附分子和趋化因子,以及它们可能通过3-羟基-3-甲基戊二酰辅酶A(HMG- CoA)还原酶抑制剂。此外,将来,新技术将使我们能够发现新的标记或一组标记,这些标记或标记可以指示预防和治疗心血管疾病的方向。 (c)2005 Prous科学。版权所有。

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