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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Searching for obesity genes: Progress and prospects.
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Searching for obesity genes: Progress and prospects.

机译：寻找肥胖基因：进展和前景。

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摘要

Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Remarkable progress has been made in the molecular elucidation of monogenic forms of obesity both in rodents and in humans. The most common form of obesity, however, is considered to be a polygenic disorder arising from the interaction of multiple genetic and environmental factors. Identification and characterization of susceptibility genes underlying obesity will contribute to a greater understanding of the pathogenesis of obesity and ultimately will assist in the development of better strategies for prevention and therapeutic intervention. In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings. (c) 2005 Prous Science. All rights reserved.
机译：肥胖是体内脂肪过多的一种状况，会导致或加剧一些主要的公共卫生问题。在啮齿动物和人类中，肥胖的单基因形式的分子阐明已经取得了显着进展。然而，肥胖的最常见形式被认为是由多种遗传和环境因素相互作用引起的多基因疾病。肥胖症易感性基因的鉴定和表征将有助于人们更好地了解肥胖症的发病机理，并最终有助于制定更好的预防和治疗干预策略。在本文中，我们讨论了肥胖症遗传解剖的现状和未来展望，重点是最惊人或最具代表性的发现。 （c）2005 Prous科学。版权所有。

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