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The genetics of osteoporosis.

机译：骨质疏松症的遗传学。

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Osteoporosis is a common health problem among the elderly, especially postmenopausal women. It is characterized by fragile bones susceptible to low-trauma fractures. Osteoporosis is a complex disease determined by genetic and environmental factors, as well as the possible interactions among these factors. Twin and family studies have shown that genetic factors play an important role in osteoporosis. Numerous genetic studies have been performed to hunt for genes underlying the disease risk. In this review, we briefly summarize and discuss the current status of knowledge about osteoporosis, with special emphasis on the progress achieved recently in: 1) heritability and choice of osteoporosis study phenotypes; 2) the approaches for gene mapping and identification for osteoporosis; 3) the candidate gene association studies; 4) the linkage mapping studies for osteoporosis; 5) some potential explanations for the inconsistent results; and 6) the pharmacogenetic studies for osteoporosis. (c) 2005 Prous Science. All rights reserved.
机译：骨质疏松症是老年人尤其是绝经后妇女中常见的健康问题。它的特点是易碎的骨头易受低创伤骨折的影响。骨质疏松症是由遗传和环境因素以及这些因素之间可能的相互作用所决定的复杂疾病。双胞胎和家族研究表明，遗传因素在骨质疏松症中起重要作用。已经进行了大量的遗传研究以寻找潜在的疾病风险基因。在这篇综述中，我们简要总结和讨论了有关骨质疏松症知识的现状，特别着重于最近在以下方面取得的进展：1）遗传性和骨质疏松症研究表型的选择; 2）骨质疏松症的基因定位和鉴定方法; 3）候选基因关联研究; 4）骨质疏松症的连锁作图研究; 5）结果不一致的一些潜在解释; 6）骨质疏松症的药物遗传学研究。 （c）2005 Prous科学。版权所有。

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