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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Mechanisms underlying status epilepticus.
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Mechanisms underlying status epilepticus.

机译：癫痫持续状态的潜在机制。

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Status epilepticus is a state of prolonged or recurrent seizure activity that is associated with significant mortality and morbidity. At a cellular level, status epilepticus results from a failure of normal inhibitory pathways, primarily mediated by gamma-n-aminobutyric acid (GABA) acting via GABA(A) receptors. This loss of inhibitory drive allows the activation of excitatory feedback loops, leading to repetitive, synchronous firing of large groups of neurons. As seizure activity continues, there is further decline in GABAergic function. Continued excitatory input mediated primarily by glutamate leads to neuronal cell death. These alterations in inhibitory and excitatory pathways have important implications for the pharmacologic management of status epilepticus. Currently recommended agents act primarily through the GABA(A) receptor and have been shown to become less effective in status epilepticus of longer duration. Agents designed to inhibit glutamate activity show promise both in the treatment of status epilepticus and in the prevention of associated neuronal injury. (c) 2005 Prous Science. All rights reserved.
机译：癫痫持续状态是癫痫发作持续或反复发作​​的状态，与显着的死亡率和发病率有关。在细胞水平上，癫痫持续状态是由正常抑制途径的失败引起的，该抑制途径的失败主要是由通过GABA（A）受体起作用的γ-n-氨基丁酸（GABA）介导的。这种抑制性驱动力的丧失会激活兴奋性反馈回路，从而导致大量神经元的重复同步放电。随着癫痫发作活动的继续，GABA能功能进一步下降。主要由谷氨酸介导的持续兴奋性输入导致神经元细胞死亡。抑制性和兴奋性途径的这些改变对于癫痫持续状态的药理管理具有重要意义。目前推荐的药物主要通过GABA（A）受体发挥作用，并已被证明在持续时间较长的癫痫持续状态中效果较差。设计用于抑制谷氨酸活性的试剂在治疗癫痫持续状态和预防相关的神经元损伤中均显示出希望。 （c）2005 Prous科学。版权所有。

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