• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Daptomycin: A new drug class for the treatment of Gram-positive infections.
【24h】

Daptomycin: A new drug class for the treatment of Gram-positive infections.

机译：达托霉素：一种用于治疗革兰氏阳性感染的新药。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. In September 2003, daptomycin was approved for the treatment of Gram-positive infections associated with complicated skin and skin structure infections. A key feature of daptomycin is its rapid, concentration-dependent bactericidal activity against significant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate and -resistant S. aureus and vancomycin-resistant Enterococcus faecalis and Enterococcus faecium (VRE). Daptomycin also has a unique mechanism of action, no cross-resistance with any other class of antibiotic and a relatively prolonged concentration-dependent postantibiotic effect in vitro. In the United States, daptomycin has been approved for use at a dose of 4 mg/ kg once daily in the treatment of S. aureus (including methicillin-resistant strains), three beta-hemolytic streptococci (S. pyogenes, S. agalactiae and S. dysgalactiae subsp. equisimilis) and E. faecalis associated with complicated skin and skin structure infections. In addition, daptomycin is undergoing a phase III evaluation for the treatment of bacteremia and endocarditis due to S. aureus. With its once-daily dosing, favorable safety profile and low potential for resistance, daptomycin is a powerful new antibiotic therapy against Gram-positive infections. (c) 2005 Prous Science. All rights reserved.
机译：达托霉素是新型杀菌抗生素，环脂肽的第一个成员。 2003年9月，达托霉素被批准用于治疗与复杂皮肤和皮肤结构感染相关的革兰氏阳性感染。达托霉素的关键特征是其对重要的革兰氏阳性病原体具有快速，浓度依赖性的杀菌活性，这些病原体包括耐甲氧西林的金黄色葡萄球菌，糖肽中间和耐金黄色葡萄球菌以及耐万古霉素的粪肠球菌和粪肠球菌（VRE）。达托霉素还具有独特的作用机理，与任何其他种类的抗生素均无交叉耐药性，并且在体外具有相对较长的浓度依赖性抗生素作用。在美国，达托霉素已被批准以每天一次4 mg / kg的剂量用于治疗金黄色葡萄球菌（包括耐甲氧西林的菌株），三种β-溶血性链球菌（化脓性链球菌，无乳链球菌和与复杂的皮肤和皮肤结构感染有关的S. dysgalactiae subsp。equisimilis和屎肠球菌。此外，达托霉素正在接受III期评估，以治疗由于金黄色葡萄球菌引起的菌血症和心内膜炎。达托霉素具有每日一次的给药剂量，良好的安全性和较低的耐药性，是一种针对革兰氏阳性感染的强有力的新型抗生素疗法。 （c）2005 Prous科学。版权所有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号