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Cerebrolysin in Alzheimer's disease.

机译：脑溶素在阿尔茨海默氏病中。

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Cerebrolysin is a neuropeptide preparation mimicking the action of endogenous neurotrophic factors. Positive effects of Cerebrolysin on beta-amyloid- and tau-related pathologies, neuroinflammation, neurotrophic factors, oxidative stress, excitotoxicity, neurotransmission, brain metabolism, neuroplasticity, neuronal apoptosis and degeneration, neurogenesis and cognition were demonstrated in experimental conditions. These pleiotropic effects of Cerebrolysin on Alzheimer's disease-related pathogenic events are consistent with a neurotrophic-like mode of action, and seems to involve the activation of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 beta intracellular signaling pathway. The clinical efficacy of Cerebrolysin in Alzheimer's disease was evaluated in several randomized, double-blind, clinical trials, showing consistent benefits on global clinical function and cognition, improvements in behavior at high doses, and minor effects on daily living activities in patients with mild to moderate Alzheimer's disease, as well as in subgroups of moderate to moderately severe patients. In addition, the clinical benefits of Cerebrolysin were largely maintained for several months after ending treatment, a finding that supports its discontinuous administration. Cerebrolysin was generally well tolerated and did not induce significant adverse events in Alzheimer's patients. Although long-term studies are needed, the data available suggest that Cerebrolysin is effective as monotherapy and constitutes a promising option for combined therapy in Alzheimer's disease.
机译：脑溶素是一种模拟内源性神经营养因子作用的神经肽制剂。在实验条件下证明了脑溶素对β-淀粉样蛋白和tau相关病理，神经炎症，神经营养因子，氧化应激，兴奋性毒性，神经传递，脑代谢，神经可塑性，神经元凋亡和变性，神经发生和认知有积极作用。脑溶素对阿尔茨海默氏病相关致病事件的多效性作用与神经营养样作用方式一致，并且似乎涉及磷脂酰肌醇3激酶/ Akt /糖原合酶激酶3β细胞内信号通路的激活。在几项随机，双盲，临床试验中评估了脑溶血素在阿尔茨海默氏病中的临床疗效，显示对整体临床功能和认知具有一致的益处，大剂量行为改善，对轻度至轻度患者的日常生活活动影响较小中度阿尔茨海默氏病，以及中至重度患者的亚组。此外，脑溶素的临床益处在结束治疗后的几个月中基本保持不变，这一发现支持其不连续给药。在阿尔茨海默氏病患者中，脑溶血素的耐受性一般良好，不会引起明显的不良事件。尽管需要长期研究，但现有数据表明脑溶血素作为单一疗法有效，并且是阿尔茨海默氏病联合疗法的有希望的选择。

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