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首页> 外文期刊>Drug and alcohol review >Modelling crack cocaine use trends over 10 years in a Canadian setting
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Modelling crack cocaine use trends over 10 years in a Canadian setting

机译:在加拿大设定10年间可卡因的使用趋势建模

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Introduction and Aims. Crack cocaine use among illicit drug users is associated with a range of health and community harms. However, long-term epidemiological data documenting patterns and risk factors for crack use initiation remain limited especially among injection drug users. We investigated longitudinal patterns of crack cocaine use among polydrug users in Vancouver, Canada. Design and Methods. We examined the rate of crack use among injection drug users enrolled in a prospective cohort study in Vancouver, Canada between 1996 and 2005. We also used a Cox proportional hazards regression analysis to identify independent predictors of crack use initiation among this population. Results. In total, 1603 injection drug users were recruited between May 1996 and December 2005. At baseline, 7.4% of participants reported ever using crack and this rate increased to 42.6% by the end of the study period (Mantel trend test P < 0.001). Independent predictors of crack use initiation during the study period included frequent cocaine injection, crystal methamphetamine injection, residency in the city's drug using epicenter and involvement in the sex trade (all P < 0.05). Discussion and Conclusions. These findings demonstrate a massive increase in crack use among injection drug users in a Canadian setting. Our findings also highlight the complex interactions that contribute to the initiation of crack use among injection drug users and suggest that evidence-based interventions are urgently needed to address crack use initiation and to address harms associated with its ongoing use.
机译:简介和目的。非法吸毒者滥用可卡因与一系列健康和社区危害有关。但是,长期的流行病学数据,尤其是在注射吸毒者中,记录裂纹使用开始的模式和危险因素的记录仍然很有限。我们调查了加拿大温哥华多毒品使用者中使用可卡因的纵向模式。设计和方法。我们研究了1996年至2005年在加拿大温哥华进行的一项前瞻性队列研究的注射吸毒者中使用裂纹的比率。我们还使用Cox比例风险回归分析来确定该人群中使用裂纹的独立预测因子。结果。在1996年5月至2005年12月之间,总共招募了1603名注射吸毒者。在基线时,有7.4%的参与者报告曾经使用过破解软件,并且在研究期结束时这一比率增加到42.6%(Mantel趋势测试P <0.001)。在研究期间,开始使用裂纹的独立预测因素包括频繁注射可卡因,注射甲基苯丙胺,使用震中在城市毒品中的居住权以及参与性交易(所有P <0.05)。讨论和结论。这些发现表明,在加拿大,注射吸毒者使用裂纹的数量大大增加。我们的研究结果还强调了导致注射吸毒者开始使用裂纹的复杂相互作用,并提出了迫切需要基于证据的干预措施,以解决裂纹使用的起始问题并解决与其持续使用相关的危害。

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