Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs

Ozlem Derinbay Ekici; Nermin Isik

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Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs

机译：肌肉注射咪唑威后对健康羔羊的血液参数的改变

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The aim of this study was to determine the safety of imidocarb dipropionate in sheep. Imidocarb dipropionate (IMDP) was administered (2.4mg/kg, intramuscular; i.m.) to 10 sheep, and blood samples were obtained 0,1, 6, and 9 days after treatment. Hemacell counts, serum biochemical values, coagulation values, and serum oxidative status were measured. IMDP caused transient decreases in pH, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, lactate dehydrogenase, and retinol levels and transient increases in serum creatine kinase-MB, blood urea nitrogen, and creatinine levels. IMDP decreased adenosine deaminase activity, antithrombin III, and superoxide dismutase activity and increased white blood cell counts. In conclusion, IMDP may change serum oxidative status and cause coagulation disorders during treatment in sheep.

机译：这项研究的目的是确定在羊中丙二胺基咪唑的安全性。向10只绵羊施用（2.4mg / kg，肌内; i.m。）亚氨基甲酸二丙酯（IMDP），并在治疗后0、1、6和9天获得血样。测量血细胞计数，血清生化值，凝血值和血清氧化状态。 IMDP导致pH值，实际的碳酸氢根，标准的碳酸氢根，总二氧化碳，体内的碱过量，体外的碱过量，氧饱和度，乳酸脱氢酶和视黄醇水平瞬时降低，血清肌酸激酶-MB，血尿素氮瞬时升高，和肌酐水平。 IMDP降低了腺苷脱氨酶活性，抗凝血酶III和超氧化物歧化酶活性，并增加了白细胞计数。总之，IMDP可能会改变绵羊治疗过程中的血清氧化状态并引起凝血障碍。

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《Drug and Chemical Toxicology》 |2012年第2期|共5页
作者
Ozlem Derinbay Ekici; Nermin Isik;
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正文语种 eng
中图分类毒物学（毒理学）;
关键词
Imidocarb dipropionate; safety; lamb;

机译：亚氨基丙酸二丙酯;安全性;羔羊;

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Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs

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