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首页> 外文期刊>Doklady Biological Sciences >The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells.
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The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells.

机译：突触蛋白荷马1c与目标蛋白的解偶联以人类神经母细胞瘤细胞中的神经递质类似的方式激活了存储操纵的钙进入。

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摘要

Activation of neurotransmitter receptors coupled to Gproteins activating phospholipase C in the plasma membrane (PM) of neuronal cells leads to an increase in the inositol 1,4,5trisphosphate (IP3 ) con centration, the activation of inositol 1,4,5trisphos phate receptor (IP3R), and, consequently, the release of calcium from the lumen of endoplasmic reticulum (ER). The increase in the calcium concentration in the cytoplasm activates ryanodine receptor (RyR), which also leads to release of calcium from ER [1]. Due to decrease in calcium concentration in ER, there are a signal transmission by calcium sensors STIM1 and STIM2 in ER to storeoperated calcium channels in PM, their activation, and calcium influx into the cell [2]. TRPC proteins (subunits of store operated calcium channels), metabotropic glutamate receptors (mGluR), RyR, and IP3R are the target pro teins specifically binding the adapter protein Homer 1c [3–6]. Oligomers of Homer 1c associated with target proteins form large molecular complexes and establish signal transmission in the area of postsynaptic density of neurons [4]. It has been suggested that adapter pro tein Homer 1c may take part in the regulation of sig naling from neurotransmitter to intracellular stores and storeoperated calcium channels in neurons.
机译：与G蛋白偶联的神经递质受体的激活会激活神经元细胞质膜（PM）中的磷脂酶C，导致肌醇1,4,5三磷酸（IP3）浓度增加，肌醇1,4,5三磷酸磷酸盐受体（ IP3R），因此从内质网（ER）腔释放钙。细胞质中钙浓度的增加会激活ryanodine受体（RyR），这也导致钙从ER中释放出来[1]。由于内质网中钙浓度的降低，内质网中的钙传感器STIM1和STIM2通过信号传输到PM中储存的钙通道，它们的活化以及钙流入细胞内[2]。 TRPC蛋白（储存的钙通道的亚基），代谢型谷氨酸受体（mGluR），RyR和IP3R是与结合蛋白Homer 1c特异性结合的目标蛋白[3-6]。与靶蛋白结合的荷马1c寡聚物形成大分子复合物，并在神经元的突触后密度区域建立信号传递[4]。有人提出，衔接蛋白Homer 1c可能参与信号转导的调控，从神经递质到神经元的细胞内存储和钙离子通道。

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